Evidence map›Paper›PMID 35349089›Full record

ReviewApplied biochemistry and biotechnology2022

Fungal Endophytes: an Accessible Source of Bioactive Compounds with Potential Anticancer Activity.

Nilesh Rai, Priyamvada Gupta, Priyanka Kumari Keshri, Ashish Verma, Pradeep Mishra, Deepak Kumar, Ajay Kumar, Santosh Kumar Singh, Vibhav Gautam

Abstract readReview
PubMed Publisher
In one paragraph

Review in Applied biochemistry and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Ethyl Acetate Extract ofACS omega · 2023
    Article
  16. Article
  17. Article
  18. Review
  19. Isolation, Identification and Screening of Saharan Actinomycete StrainInternational journal of molecular and cellular medicine · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nilesh Rai *Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, 221005, Varanasi, India.
Priyamvada Gupta *Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, 221005, Varanasi, India.
Priyanka Kumari Keshri *Centre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, 221005, Varanasi, India.
Ashish VermaCentre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, 221005, Varanasi, India.
Pradeep MishraDepartment of Medical Biochemistry and Biophysics Kemihuset (K), Umeå Universitet, Umeå Campus, 901 87, Umeå, Sweden.
Deepak KumarDepartment of Botany, Institute of Science, Banaras Hindu University, 221005, Varanasi, India.
Ajay KumarDepartment of Zoology, Institute of Science, Banaras Hindu University, 221005, Varanasi, India.
Santosh Kumar SinghCentre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, 221005, Varanasi, India.
Vibhav GautamCentre of Experimental Medicine and Surgery, Institute of Medical Sciences, Banaras Hindu University, 221005, Varanasi, India. vibhav.gautam4@bhu.ac.in.

Funding

University Grants Commission University Grants Commission
6 · The paper itself

Abstract

Endophytes either be bacteria, fungi, or actinomycetes colonize inside the tissue of host plants without showing any immediate negative effects on them. Among numerous natural alternative sources, fungal endophytes produce a wide range of structurally diverse bioactive metabolites including anticancer compounds. Considering the production of bioactive compounds in low quantity, genetic and physicochemical modification of the fungal endophytes is performed for the enhanced production of bioactive compounds. Presently, for the treatment of cancer, chemotherapy is majorly used, but the side effects of chemotherapy are of prime concern in clinical practices. Also, the drug-resistant properties of carcinoma cells, lack of cancer cells-specific medicine, and the side effects of drugs are the biggest obstacles in cancer treatment. The interminable requirement of potential drugs has encouraged researchers to seek alternatives to find novel bioactive compounds, and fungal endophytes seem to be a probable target for the discovery of anticancer drugs. The present review focuses a comprehensive literature on the major fungal endophyte-derived bioactive compounds which are presently been used for the management of cancer, biotic factors influencing the production of bioactive compounds and about the challenges in the field of fungal endophyte research.

Indexed as

Antineoplastic AgentsEndophytesBacteriaFungiPlantsAntineoplastic AgentsAnticancer activityBioactive compoundEpigenetic modifierFungal endophytesPaclitaxelPodophyllotoxin

Identifiers

PMID35349089

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.