Evidence map›Paper›PMID 35348983›Full record

Observational studyJapanese journal of ophthalmology2022

Multicenter prospective observational study of fungal keratitis in Japan: analyses of in vitro susceptibility tests for combinations of drugs.

Keigo Kimura, Yoshitsugu Inoue, Seishi Asari, Atsuko Sunada, Yuichi Ohashi, Yoshikazu Shimomura, Chie Sotozono, Hiroshi Hatano, Masahiko Fukuda, Hiroshi Eguchi and 7 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Japanese journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 12 institutions in 1 country.

Keigo KimuraLaboratory for Clinical Investigation, Osaka University Hospital, Osaka, Japan.
Yoshitsugu InoueDivision of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago, Tottori, 683-8504, Japan. yoinoue@grape.med.tottori-u.ac.jp.
Seishi AsariLaboratory for Clinical Investigation, Osaka University Hospital, Osaka, Japan.
Atsuko SunadaLaboratory for Clinical Investigation, Osaka University Hospital, Osaka, Japan.
Yuichi OhashiDepartment of Ophthalmology, Minami-Matsuyama Hospital, Matsuyama, Ehime, Japan.
Yoshikazu ShimomuraDepartment of Ophthalmology, Fuchu Hospital, Izumi, Osaka, Japan.
Chie SotozonoDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Hiroshi HatanoHatano Eye Clinic, Fujisawa, Kanagawa, Japan.
Masahiko FukudaDepartment of Ophthalmology, Kindai University Nara Hospital, Ikoma, Nara, Japan.
Hiroshi EguchiDepartment of Ophthalmology, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan.
Kaoru Araki-SasakiDepartment of Ophthalmology, Kansai Medical University, Hirakata, Osaka, Japan.
Takashi SuzukiDepartment of Ophthalmology, Faculty of Medicine, Toho University, Tokyo, Japan.
Saichi HoshiHorikiri Eye Clinic, Tokyo, Japan.
Toru TobeDepartment of Biomedical Informatics, Osaka University Graduate School of Medicine, Osaka, Japan.
Takashi YaguchiMedical Mycology Research Center, Chiba University, Chiba, Japan.
Koichi MakimuraInstitute of Medical Mycology, Teikyo University, Tokyo, Japan.
Multicenter Study Group of Fungal Keratitis in Japan
Kindai University · JPOsaka University Hospital · JPSaiseikai Matsuyama Hospital · JPChiba University Hospital · JPMinamiaoyama Eye Clinic · JPFuchu Hospital · JPKansai Medical University · JPTeikyo University · JPToho University · JPTottori University · JPKyoto Prefectural University of Medicine · JPThe University of Osaka · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine the effects of a combination of two antifungal drugs against causative fungi of fungal keratitis in Japan. STUDY

designMulticenter prospective observational study.

methodsEighteen isolates of yeast-like fungi and 22 isolates of filamentous fungi collected by the Multicenter Prospective Observational Study of Fungal Keratitis in Japan were studied. Specially manufactured minimum inhibitory concentration (MIC) measurement plates were used to test the effectiveness of 10 combinations of two antifungal drugs against the isolates. The combinations were pimaricin (PMR) + voriconazole (VRCZ), PMR + fluconazole (FLCZ), PMR + miconazole (MCZ), PMR + micafungin (MCFG), VRCZ + FLCZ, VRCZ + MCZ, VRCZ + MCFG, VRCZ + amphotericin-B (AMPH-B), MCZ + FLCZ, and MCZ + MCFG. The checkerboard microdilution method was used, and the fractional inhibitory concentration (FIC) index was calculated based on the guidelines of The Clinical & Laboratory Standards Institute (CLSI).

resultsIn yeast-like fungi, additive effects were observed between PMR and MCFG in 77.8% of the isolates, and they were also observed between the azoles. Synergistic effects were observed on 11.1% of the isolates for MCZ and FLCZ. On the other hand, antagonistic effects were present between PMR and azoles with 88.9% between PMR and VRCZ, 72.2% between PMR and FLCZ, and 94.4% between PMR and MCZ. In filamentous fungi, additive effects were observed between PMR and MCFG in 40.9% of the isolates, and between VRCZ and MCZ in 40.9% of the isolates. Antagonistic effects were observed for PMR and the azoles.

conclusionsThe combination of drugs prescribed for fungal keratitis incurs a possibility of synergistic, additive, indifferent, or antagonistic effects, depending on drug combinations and fungal strains.

Indexed as

Eye Infections, FungalKeratitisAntifungal AgentsAzolesFluconazoleFungiHumansJapanSaccharomyces cerevisiaeAntifungal AgentsAzolesFluconazoleDrug susceptibility testFilamentous fungiFractional inhibitory concentration (FIC) indexFungal keratitisYeast-like fungi

Identifiers

PMID35348983
OpenAlexW4220841017

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.