Evidence map›Paper›PMID 35348982›Full record

Observational studyJapanese journal of ophthalmology2022

Multicenter prospective observational study of fungal keratitis in Japan: analyses of culture-positive cases.

Yoshitsugu Inoue, Yuichi Ohashi, Yoshikazu Shimomura, Chie Sotozono, Hiroshi Hatano, Masahiko Fukuda, Hiroshi Eguchi, Kaoru Araki-Sasaki, Takashi Suzuki, Saichi Hoshi and 6 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Japanese journal of ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 11 institutions in 1 country.

Yoshitsugu InoueDivision of Ophthalmology and Visual Science, Faculty of Medicine, Tottori University, 36-1 Nishi-cho, Yonago, Tottori, 683-8504, Japan. yoinoue@grape.med.tottori-u.ac.jp.
Yuichi OhashiDepartment of Ophthalmology, Minami-Matsuyama Hospital, Matsuyama, Ehime, Japan.
Yoshikazu ShimomuraDepartment of Ophthalmology, Fuchu Eye Center, Izumi, Osaka, Japan.
Chie SotozonoDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Hiroshi HatanoHatano Eye Clinic, Fujisawa, Kanagawa, Japan.
Masahiko FukudaDepartment of Ophthalmology, Kindai University Nara Hospital, Ikoma, Nara, Japan.
Hiroshi EguchiDepartment of Ophthalmology, Kindai University Faculty of Medicine, Osakasayama, Osaka, Japan.
Kaoru Araki-SasakiDepartment of Ophthalmology, Kansai Medical University, Hirakata, Osaka, Japan.
Takashi SuzukiDepartment of Ophthalmology, Faculty of Medicine, Toho University, Tokyo, Japan.
Saichi HoshiHorikiri Eye Clinic, Tokyo, Japan.
Seishi AsariLaboratory for Clinical Investigation, Osaka University Hospital, Osaka, Japan.
Atsuko SunadaLaboratory for Clinical Investigation, Osaka University Hospital, Osaka, Japan.
Keigo KimuraLaboratory for Clinical Investigation, Osaka University Hospital, Osaka, Japan.
Takashi YaguchiMedical Mycology Research Center, Chiba University, Chiba, Japan.
Koichi MakimuraInstitute of Medical Mycology, Teikyo University, Tokyo, Japan.
Multicenter Study Group of Fungal Keratitis in Japan
Osaka University Hospital · JPKindai University · JPMinamiaoyama Eye Clinic · JPChiba University Hospital · JPFuchu Hospital · JPKansai Medical University · JPKyoto Prefectural University of Medicine · JPSaiseikai Matsuyama Hospital · JPTeikyo University · JPToho University · JPTottori University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the clinical characteristics and causative fungi in patients with fungal keratitis in Japan, and to determine factors related to the prognosis. STUDY

designMulticenter prospective observational study.

methodsEligible patients were enrolled from November 2011 to October 2013 at the 1st stage and from April 2015 to March 2016 at the 2nd stage. The corneal foci were scraped, and the scrapings were cultured in potato dextrose agar. The isolated fungi were identified by gene analyses. Data were collected from the clinical records and statistically analyzed by Cox and logistic regression analyses.

resultsNinety-four fungal strains were isolated from 93 cases, including 42 yeast-like fungi and 52 filamentous fungi. The fungi affected the deep layers of the cornea in 23 cases (24.7%) and the peripheral cornea in 29 cases (31.2%). The incidences of lid swelling/redness, ciliary injection, anterior chamber cells/flare, anterior chamber fibrin, and hyphate ulcer in cases of filamentous fungi were significantly higher than in yeast-like fungi. No history of topical steroids, absence of a main lesion in the peripheral cornea, and best-corrected visual acuity (BCVA) of more than 0.04 at the first visit were related to a shorter healing time. No history of ocular surgery, absence of lesion at one-third deep stromal layer and BCVA of more than 0.04 at the first visit were correlated with BCVA at 3 months after the initial examination.

conclusionFungal keratitis is caused by various species of fungi and can become refractory due to poor prognosis factors.

Indexed as

Corneal UlcerEye Infections, FungalKeratitisAntifungal AgentsFungiHumansJapanSaccharomyces cerevisiaeAntifungal AgentsFilamentous fungiFungal keratitisMulticenter studyPrognosisYeast-like fungi

Identifiers

PMID35348982
OpenAlexW4220987899

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.