Evidence map›Paper›PMID 35348908›Full record

ArticleMikrochimica acta2022

Simple and sensitive nitric oxide biosensor based on the electrocatalysis of horseradish peroxidase on AuNPs@metal-organic framework composite-modified electrode.

Yong Wang, Youting Zhou, Yangjie Chen, Zhihang Yin, Juan Hao, Huiming Li, Kunping Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mikrochimica acta, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yong WangAntibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province, Chengdu University, Chengdu, 610106, China.
Youting ZhouAntibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province, Chengdu University, Chengdu, 610106, China.
Yangjie ChenAntibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province, Chengdu University, Chengdu, 610106, China.
Zhihang YinAntibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province, Chengdu University, Chengdu, 610106, China.
Juan HaoAntibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province, Chengdu University, Chengdu, 610106, China.
Huiming LiKey Laboratory of Medicinal and Edible Plants Resources Development of Sichuan Education Department, Chengdu University, Chengdu, 610106, China. lihuiming@cdu.edu.cn.
Kunping LiuAntibiotics Research and Re-Evaluation Key Laboratory of Sichuan Province, Chengdu University, Chengdu, 610106, China. liukunping@cdu.edu.cn.ORCID 0000-0001-9490-2889

Funding

Second Tibetan Plateau Scientific Expedition and Research Program (STEP) 2019QZKK0201
6 · The paper itself

Abstract

Fe-based metal-organic framework (MIL-101(Fe)) was synthesized through a simple solvothermal synthesis and then used to prepare the AuNPs-decorated MIL-101(Fe) nanocomposite (APPPM(Fe)) by a multi-step layer-by-layer assembly process. Benefited from the porous structure of MIL-101(Fe) and the multilayer assemble process, the loading amount of AuNPs on APPPM(Fe) was enhanced and exhibited a fine biocompatible interface and high conductivity. Through the intense Au-S bond, high loading amount of horseradish peroxidase was immobilized on APPPM(Fe) and the native bioactivity of HRP was kept to realize its direct electrochemistry. From the electrochemical kinetics, the constructed biosensor displayed fast electron transfer and good electrocatalysis activity for the detection of nitric oxide (NO) with wide linear range from 0.033 to 5370 μM and a low detection limit of 0.01 μM (3 σ) as well as fine stability, reproducibility and specificity. According to results of real sample analysis, the proposed electrochemical biosensor offers fast and simple detection of NO in real serum. Therefore, the present strategy definitely provided a potential application prospect in NO clinic detection and disease therapy.

Indexed as

Biosensing TechniquesMetal NanoparticlesMetal-Organic FrameworksElectrodesGoldHorseradish PeroxidaseNitric OxideReproducibility of ResultsGoldHorseradish PeroxidaseMetal-Organic FrameworksNitric OxideBiosensorElectrocatalysisHorseradish peroxidaseMetal–organic frameworkNanocompositeNitric oxide

Identifiers

PMID35348908
PMCPMC8961095

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.