Evidence map›Paper›PMID 35348907›Full record

ArticleInsights into imaging2022

The utility of splenic imaging parameters in cardiac magnetic resonance for the diagnosis of immunoglobulin light-chain amyloidosis.

Niki Lama, Alexandros Briasoulis, Efstratios Karavasilis, Kimon Stamatelopoulos, Angeliki Chasouraki, Efthymia Alexopoulou, Stavros Spiliopoulos, Foteini Theodorakakou, Meletios Athanasios Dimopoulos, Efstathios Kastritis and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Insights into imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Observational
  2. Imaging Advances in Light Chain Amyloidosis.Diagnostics (Basel, Switzerland) · 2026
    Review
  3. Article
  4. JACC. Advances · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Niki LamaResearch Unit of Radiology and Medical Imaging, 2nd Department of Radiology, Medical School, Faculty of Medicine, National and Kapodistrian University of Athens, Papadiamantopoulou 19, 11528, Athens, Greece. niklampatr@gmail.com.ORCID http://orcid.org/0000-0003-0899-0515
Alexandros BriasoulisDepartment of Clinical Therapeutics, Medical School, Faculty of Medicine, National Kapodistrian University of Athens, Vasilissis Sofias 80, 11528, Athens, Greece. alexbriasoulis@gmail.com.
Efstratios KaravasilisResearch Unit of Radiology and Medical Imaging, 2nd Department of Radiology, Medical School, Faculty of Medicine, National and Kapodistrian University of Athens, Papadiamantopoulou 19, 11528, Athens, Greece.
Kimon StamatelopoulosDepartment of Clinical Therapeutics, Medical School, Faculty of Medicine, National Kapodistrian University of Athens, Vasilissis Sofias 80, 11528, Athens, Greece.
Angeliki ChasourakiDepartment of Clinical Therapeutics, Medical School, Faculty of Medicine, National Kapodistrian University of Athens, Vasilissis Sofias 80, 11528, Athens, Greece.
Efthymia AlexopoulouResearch Unit of Radiology and Medical Imaging, 2nd Department of Radiology, Medical School, Faculty of Medicine, National and Kapodistrian University of Athens, Papadiamantopoulou 19, 11528, Athens, Greece.
Stavros SpiliopoulosResearch Unit of Radiology and Medical Imaging, 2nd Department of Radiology, Medical School, Faculty of Medicine, National and Kapodistrian University of Athens, Papadiamantopoulou 19, 11528, Athens, Greece.
Foteini TheodorakakouDepartment of Clinical Therapeutics, Medical School, Faculty of Medicine, National Kapodistrian University of Athens, Vasilissis Sofias 80, 11528, Athens, Greece.
Meletios Athanasios DimopoulosDepartment of Clinical Therapeutics, Medical School, Faculty of Medicine, National Kapodistrian University of Athens, Vasilissis Sofias 80, 11528, Athens, Greece.
Efstathios KastritisDepartment of Clinical Therapeutics, Medical School, Faculty of Medicine, National Kapodistrian University of Athens, Vasilissis Sofias 80, 11528, Athens, Greece.
Nikolaos L KelekisResearch Unit of Radiology and Medical Imaging, 2nd Department of Radiology, Medical School, Faculty of Medicine, National and Kapodistrian University of Athens, Papadiamantopoulou 19, 11528, Athens, Greece.
National and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesCardiac magnetic resonance (CMR) imaging is a key test in the diagnosis of cardiac amyloidosis (CA). Extracardiac involvement is common in light chain (AL) amyloidosis and MRI findings may assist in its diagnosis. We sought to investigate the utility of splenic CMR parameters for the diagnosis of CA.

methodsThirty-four patients with AL amyloidosis and 32 patients with severe left ventricular hypertrophy in the setting of aortic stenosis (LVH-AS) who completed 3T cardiac MRI at the time of their diagnosis of AL or LVH-AS were assessed with T1, T2 (modified Look-Locker inversion recovery), extracellular volume (ECV) mapping, and late gadolinium enhancement (LGE) imaging of the heart and spleen.

resultsAge, left ventricular mass index, wall thickness, ejection fraction, and splenic dimensions did not differ significantly between groups. All AL patients had cardiac involvement. T1 and T2 spleen mapping did not differ significantly between groups but AL patients had higher median ECV in the spleen than in LVH-AS (AL 46.9%, LVH-AS: 31%, p < 0.001), and significantly lower short tau inversion recovery ratio (AL: 1.7, LVH-AS: 2.7, p < 0.001) both with very good diagnostic performance to diagnose AL. We identified 16 AL patients with spleen involvement and 16 without. Spleen ECV and "normalized" spleen ratio, defined as the ratio of spleen LGE to muscle values exhibited strong correlation and had excellent diagnostic performance to discriminate those with spleen involvement.

conclusionOur findings show that spleen CMR parameters can identify spleen involvement in AL patients and differentiate them from those without AL amyloidosis.

Indexed as

AmyloidosisCMRSpleen involvement

Identifiers

PMID35348907
PMCPMC8964909
OpenAlexW4220945688

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.