ArticlePlant physiology2022
Extracellular ATP plays an important role in systemic wound response activation.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Defective cuticle-derived signals enhance extracellular ATP response and plant immunity.The New phytologist · 2026Article
- The zig-zag model of molecular defense and counterdefense in plant-herbivore interactions.Planta · 2026Review
- Unraveling the crosstalk between extracellular ATP and glutamate in systemic ROS signaling.Plant physiology · 2026Article
- The chitin receptor-interacting protein LIK1 regulates extracellular ATP signaling via interaction with P2K1 inbioRxiv : the preprint server for biology · 2026Article
- Soil-borne diseases in medicinal plants: linking allelopathy and host immunity to microbiome-based interventions.Frontiers in plant science · 2026Review
- bHLH35 mediates specificity in plant responses to multiple stress conditions.Science advances · 2025Article
- Arabidopsis thaliana Cyclic Nucleotide-Gated Channel 19 is involved in root extracellular ATP and Pep1 signalling.The New phytologist · 2025Article
- eATP sensing by the purinergic receptor PA2072 for allosteric modulation in intracellular c-di-GMP signaling.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Jasmonate primes plant responses to extracellular ATP.The Plant journal : for cell and molecular biology · 2025Article
- Spatially Resolved Plant Metabolomics.Metabolites · 2025Review
- RBOHD, GLR3.3, and GLR3.6 cooperatively control wounding hypocotyl-induced systemic CaPlant diversity · 2025Article
- Extracellular ATP: an emerging multifaceted regulator of plant fitness.Plant biotechnology journal · 2025Review
- The "plant neurobiology" revolution.Plant signaling & behavior · 2024Review
- Growth regulation by apyrases: Insights from altering their expression level in different organisms.Plant physiology · 2024Review
- Proteins extracted from pearl oyster (Heliyon · 2024Article
- Computational prediction andPlant signaling & behavior · 2023Article
- Phosphorylation-mediated regulation of integrin-linked kinase 5 by purinoreceptor P2K2.Plant signaling & behavior · 2023Article
- The Plasma Membrane Purinoreceptor P2K1/DORN1 Is Essential in Stomatal Closure Evoked by Extracellular Diadenosine Tetraphosphate (ApInternational journal of molecular sciences · 2023Article
- Salt stress releases extracellular ATP to activate purinergic signaling and inhibit plant growth.Plant physiology · 2023Article
- The Raf-like MAPKKK INTEGRIN-LINKED KINASE 5 regulates purinergic receptor-mediated innate immunity in Arabidopsis.The Plant cell · 2023Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Mechanical wounding occurs in plants during biotic or abiotic stresses and is associated with the activation of long-distance signaling pathways that trigger wound responses in systemic tissues. Among the different systemic signals activated by wounding are electric signals, calcium, hydraulic, and reactive oxygen species (ROS) waves. The release of glutamate (Glu) from cells at the wounded tissues was recently proposed to trigger systemic signal transduction pathways via GLU-LIKE RECEPTORs (GLRs). However, the role of another important compound released from cells during wounding (extracellular ATP [eATP]) in triggering systemic responses is not clear. Here, we show in Arabidopsis (Arabidopsis thaliana) that wounding results in the accumulation of nanomolar levels of eATP and that these levels are sufficient to trigger the systemic ROS wave. We further show that the triggering of the ROS wave by eATP during wounding requires the PURINORECEPTOR 2 KINASE (P2K) receptor. Application of eATP to unwounded leaves triggered the ROS wave, and the activation of the ROS wave by wounding or eATP application was suppressed in mutants deficient in P2Ks (e.g. p2k1-3, p2k2, and p2k1-3p2k2). In addition, expression of systemic wound response (SWR) transcripts was suppressed in mutants deficient in P2Ks during wounding. Interestingly, the effect of Glu and eATP application on ROS wave activation was not additive, suggesting that these two compounds function in the same pathway to trigger the ROS wave. Our findings reveal that in addition to sensing Glu via GLRs, eATP sensed by P2Ks plays a key role in the triggering of SWRs in plants.
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