ArticleThe American journal of clinical nutrition2022
Ultraprocessed food consumption and kidney function decline in a population-based cohort in the Netherlands.
Article in The American journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Ultra-Processed Food and Chronic Kidney Disease Risk: A Systematic Review, Meta-Analysis, and Recommendations.Nutrients · 2025Pooled it
- Ultra-processed foods and risk of declined renal function: a dose-response meta-analysis of 786,216 participants.Journal of health, population, and nutrition · 2025Pooled it
- Ultra-processed food consumption and the risk of incident chronic kidney disease: a systematic review and meta-analysis of cohort studies.Renal failure · 2024Pooled it
- Ultra-processed food consumption and chronic kidney disease risk: a systematic review and dose-response meta-analysis.Frontiers in nutrition · 2024Pooled it
- Review
- Review
- Effects of social determinants of health on the landscape of kidney disease.Nature reviews. Nephrology · 2026Review
- Ultra-Processed Foods and the Cardiovascular-Kidney-Metabolic Continuum: Integrating Epidemiological, Multi-Omics, and Translational Evidence.Nutrients · 2026Review
- Frailty progression: The role of multimorbidity configurations in frailty transitions and predicting mortality risk among older adults.BMC medicine · 2026Article
- Ultra-Processed Food Consumption, Mental Health, and Quality of Life in Adults: A Systematic Review Protocol.Health science reports · 2026Article
- Real-World Snapshot of Dietary Patterns in Subjects Living with Chronic Kidney Disease.Nutrients · 2025Article
- Review
- Multimorbidity patterns in older adults from Northern Netherlands: comparing factor analysis and latent class analysis solutions.BMC geriatrics · 2025Article
- Dietary quality and adherence to dietary recommendations in Chinese patients with chronic kidney disease.Frontiers in nutrition · 2025Article
- Fruit and Vegetable Intake Patterns, Kidney Failure, and Mortality in Adults with and without Chronic Kidney Disease in the United States.The Journal of nutrition · 2024Article
- From ultra-processed foods towards healthy eating for CKD patients: a proposal of educational infographics.Journal of nephrology · 2024Article
- Review
- The role of ultra-processed food consumption in protein-energy wasting and sarcopenia development in patients with chronic kidney diseases.BMC nephrology · 2024Article
- From Prophecy to Plate: How to Actualize a Planetary Menu for Kidney Disease Nutrition.Canadian journal of kidney health and disease · 2024Article
- Ultraprocessed foods and chronic kidney disease-double trouble.Clinical kidney journal · 2023Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUltraprocessing makes food products more convenient, appealing, and profitable. Recent studies show that high ultraprocessed food (UPF) intake is associated with cardiometabolic diseases.
objectivesThe aim of this study is to investigate the association between UPF consumption and risks of kidney function decline in the general population.
methodsIn a prospective, general population-based Lifelines cohort from Northern Netherlands, 78,346 participants free of chronic kidney disease (CKD) at baseline responded to a 110-item FFQ. We used a multivariable regression analysis to study the associations of the proportion (in grams/day) of UPFs in the total diet with a composite kidney outcome [incident CKD or a ≥30% estimated glomerular filtration rate (eGFR) decline relative to baseline] and annual change in eGFR.
resultsOn average, 37.7% of total food intake came from UPFs. After 3.6 ± 0.9 years of follow-up, 2470 participants (3.2%) reached the composite kidney outcome. Participants in the highest quartile of UPF consumption were associated with a higher risk of the composite kidney outcome (OR, 1.27; 95% CI, 1.09-1.47; P = 0.003) compared with those in the lowest quartile, regardless of their macro- or micronutrient intake or diet quality. Participants in the highest quartile had a more rapid eGFR decline (β, -0.17; 95% CI, -0.23 to -0.11; P < 0.001) compared with those in the lowest quartile. Associations were generally consistent across different subgroups.
conclusionsHigher UPF consumption was associated with a higher risk of a composite kidney outcome (incident CKD or ≥30% eGFR decline) and a more rapid eGFR decline in the general population, independent of confounders and other dietary indices.
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