ArticleDevelopmental neurobiology2022
Cortical myelination in toddlers and preschoolers with autism spectrum disorder.
Article in Developmental neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Genomic, Transcriptomic, and Regulomic Analyses Do Not Support Profound Autism as a Distinct Biological Category.bioRxiv : the preprint server for biology · 2026Article
- Cortical and white matter myelination proceed in concert during early infancy.Nature communications · 2026Article
- A Systematic Review of Functional Brain Imaging Studies in Neurofibromatosis 1.Neuropsychology review · 2026Review
- The T1-Weighted/T2-Weighted Ratio as an In Vivo Proxy for Reduced Intracortical Myelin Content in Youth With RASopathies: A Cross-Sectional Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Neurodevelopmental disorders in children: the role of MRI in early detection and intervention planning.Frontiers in neuroscience · 2026Review
- T1w/T2w ratio suggests reduced intracortical myelin content in youth with RASopathies.medRxiv : the preprint server for health sciences · 2025Article
- Article
- Leveraging AI-Driven Neuroimaging Biomarkers for Early Detection and Social Function Prediction in Autism Spectrum Disorders: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
- Cortical and white matter T1w/T2w development proceed in concert during early infancy.bioRxiv : the preprint server for biology · 2025Article
- MRI signatures of cortical microstructure in human development align with oligodendrocyte cell-type expression.Nature communications · 2025Article
- Assessment of glymphatic function and white matter integrity in children with autism using multi-parametric MRI and machine learning.European radiology · 2025Article
- Widespread associations between behavioral metrics and brain microstructure in ASD suggest age mediates subtypes of ASD.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- GABA and glutamate measurements in temporal cortex of autistic children.Autism research : official journal of the International Society for Autism Research · 2024Article
- Shank3 mutation impairs glutamate signaling and myelination in ASD mouse model and human iPSC-derived OPCs.Science advances · 2024Article
- Intracortical myelin across laminae in adult individuals with 47,XXX: a 7 Tesla MRI study.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Associations between atypical intracortical myelin content and neuropsychological functions in middle to older aged adults with ASD.Brain and behavior · 2024Article
- Functional myelin in cognition and neurodevelopmental disorders.Cellular and molecular life sciences : CMLS · 2024Review
- Reduced covariation between brain morphometry and local spontaneous activity in young children with ASD.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The Impact of Microglia on Neurodevelopment and Brain Function in Autism.Biomedicines · 2024Review
- Childhood development of brain white matter myelin: a longitudinal T1w/T2w-ratio study.Brain structure & function · 2024Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Intracortical myelin is thought to play a significant role in the development of neural circuits and functional networks, with consistent evidence of atypical network connectivity in children with autism spectrum disorder (ASD). However, little is known about the development of intracortical myelin in the first years of life in ASD, during the critical neurodevelopmental period when autism symptoms first emerge. Using T1-weighted (T1w) and T2w structural magnetic resonance imaging (MRI) in 21 young children with ASD and 16 typically developing (TD) children, ages 1.5-5.5 years, we demonstrate the feasibility of estimating intracortical myelin in vivo using the T1w/T2w ratio as a proxy. The resultant T1w/T2w maps were largely comparable with those reported in prior T1w/T2w studies in TD children and adults, and revealed no group differences between TD children and those with ASD. However, differential associations between T1w/T2w and age were identified in several early myelinated regions (e.g., visual, posterior cingulate, precuneus cortices) in the ASD and TD groups, with age-related increase in estimated myelin content across the toddler and preschool years detected in TD children, but not in children with ASD. The atypical age-related effects in intracortical myelin, suggesting a disrupted myelination in the first years of life in ASD, may be related to the aberrant brain network connectivity reported in young children with ASD in some of the same cortical regions and circuits.
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Registered trials
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