Evidence map›Paper›PMID 35348173›Full record

ArticleOrganic & biomolecular chemistry2022

A stereochemical journey around spirocyclic glutamic acid analogs.

Anton V Chernykh, Alla V Chernykh, Dmytro S Radchenko, Pratik Rajesh Chheda, Eduard B Rusanov, Oleksandr O Grygorenko, M Ashley Spies, Dmitriy M Volochnyuk, Igor V Komarov

Open access · greenAbstract read
In one paragraph

Article in Organic & biomolecular chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Anton V ChernykhEnamine Ltd, Chervonotkatska Street 78, Kyiv 02094, Ukraine.
Alla V ChernykhEnamine Ltd, Chervonotkatska Street 78, Kyiv 02094, Ukraine.
Dmytro S RadchenkoEnamine Ltd, Chervonotkatska Street 78, Kyiv 02094, Ukraine.
Pratik Rajesh ChhedaDivision of Medicinal and Natural Products Chemistry, Department of Pharmaceutics and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City 52246, Iowa, USA.
Eduard B RusanovInstitute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanska Street 5, Kyiv 02660, Ukraine.
Oleksandr O GrygorenkoEnamine Ltd, Chervonotkatska Street 78, Kyiv 02094, Ukraine.
M Ashley SpiesDivision of Medicinal and Natural Products Chemistry, Department of Pharmaceutics and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City 52246, Iowa, USA.
Dmitriy M VolochnyukEnamine Ltd, Chervonotkatska Street 78, Kyiv 02094, Ukraine.
Igor V KomarovEnamine Ltd, Chervonotkatska Street 78, Kyiv 02094, Ukraine.ORCID 0000-0002-7908-9145
Taras Shevchenko National University of Kyiv · UANational Academy of Sciences of Ukraine · UAUniversity of Iowa · US

Funding

Exploiting Enzyme Plasticity in Drug Discovery: application to glutamate racemaseR01GM097373 · NIGMS · UNIVERSITY OF IOWA · PI SPIES, MICHAEL ASHLEY · 2012 to 2020
$2.7M
NIGMS NIH HHS R01 GM097373
6 · The paper itself

Abstract

A practical divergent synthetic approach is reported for the library of regio- and stereoisomers of glutamic acid analogs built on the spiro[3.3]heptane scaffold. Formation of the spirocyclic scaffold was achieved starting from a common precursor - an

Indexed as

Glutamic AcidSpiro CompoundsCrystallography, X-RayKetonesStereoisomerismGlutamic AcidKetonesSpiro Compounds

Identifiers

PMID35348173
PMCPMC10170626
OpenAlexW4221134999

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.