Evidence map›Paper›PMID 35348114›Full record

ArticleeLife2022

Inhibiting host-protein deposition on urinary catheters reduces associated urinary tract infections.

Marissa Jeme Andersen, ChunKi Fong, Alyssa Ann La Bella, Jonathan Jesus Molina, Alex Molesan, Matthew M Champion, Caitlin Howell, Ana L Flores-Mireles

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 60 citations in OpenAlex.

  1. mBio · 2026
    Article
  2. Review
  3. Article
  4. The unique Efg1 fungal virulence regulon in the catheterized bladder environment.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. CAUTIon - not all UTIs are the same.Nature reviews. Urology · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Role of Clot Formation and Plasminogen Activation in Lower Urinary Tract Pathologies.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Marissa Jeme AndersenDepartment of Biological Sciences, College of Science, University of Notre Dame, Notre Dame, United States.
ChunKi FongDepartment of Chemical and Biomedical Engineering, College of Engineering, University of Maine, Orono, United States.
Alyssa Ann La BellaDepartment of Biological Sciences, College of Science, University of Notre Dame, Notre Dame, United States.
Jonathan Jesus MolinaDepartment of Biological Sciences, College of Science, University of Notre Dame, Notre Dame, United States.
Alex MolesanDepartment of Biological Sciences, College of Science, University of Notre Dame, Notre Dame, United States.
Matthew M ChampionDepartment of Chemistry and Biochemistry, College of Science, University of Notre Dame, Notre Dame, United States.
Caitlin HowellDepartment of Chemical and Biomedical Engineering, College of Engineering, University of Maine, Orono, United States.ORCID 0000-0002-9345-6642
Ana L Flores-MirelesDepartment of Biological Sciences, College of Science, University of Notre Dame, Notre Dame, United States.ORCID 0000-0003-4610-4246
University of Notre Dame · USUniversity of Maine · US

Funding

Understanding the role of catheter-associated protein deposition in the development of CAUTIR01DK128805 · NIDDK · UNIVERSITY OF NOTRE DAME · PI FLORES-MIRELES, ANA LIDIA, HOWELL, CAITLIN L · 2021 to 2025
$1.9M
NIDDK NIH HHS R01 DK128805
6 · The paper itself

Abstract

Microbial adhesion to medical devices is common for hospital-acquired infections, particularly for urinary catheters. If not properly treated these infections cause complications and exacerbate antimicrobial resistance. Catheter use elicits bladder inflammation, releasing host serum proteins, including fibrinogen (Fg), into the bladder, which deposit on the urinary catheter.

Indexed as

Catheter-Related InfectionsUrinary Tract InfectionsAnimalsAnti-Bacterial AgentsCandida albicansEnterococcus faecalisEscherichia coliKlebsiella pneumoniaeMiceUrinary CathetersAnti-Bacterial AgentsA. baumanniiC. albicansCAUTIE. coliE. faecalisfibrinogeninfectious diseaseinflammationK. pneumoniaeliquid-infused polymermicrobiologymouseP. aeruginosaslippery liquid-infused porous surfaceurinary catheteruropathogen

Identifiers

PMID35348114
PMCPMC8986317
OpenAlexW4220870520

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.