Evidence map›Paper›PMID 35347982›Full record

ArticleChemical research in toxicology2022

Profiling How the Gut Microbiome Modulates Host Xenobiotic Metabolism in Response to Benzo[

Whitney L Garcia, Carson J Miller, Gerard X Lomas, Kari A Gaither, Kimberly J Tyrrell, Jordan N Smith, Kristoffer R Brandvold, Aaron T Wright

Open access · greenAbstract read
In one paragraph

Article in Chemical research in toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

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  9. Combined Inhibition of the TGF-β1/Smad Pathway byInternational journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Whitney L GarciaBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States.
Carson J MillerBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States.
Gerard X LomasBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States.
Kari A GaitherBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States.
Kimberly J TyrrellBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States.
Jordan N SmithBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States.ORCID 0000-0003-3151-2810
Kristoffer R BrandvoldBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States.ORCID 0000-0001-5970-879X
Aaron T WrightBiological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States.ORCID 0000-0002-3172-5253
Pacific Northwest National Laboratory · USOregon State University · US

Funding

Research Experience and Training Coordination CoreP42ES016465 · NIEHS · OREGON STATE UNIVERSITY · PI Robyn L Tanguay · 2009 to 2026
$52.5M
Defining the functional dynamics of the microbiomeR21ES029319 · NIEHS · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI WRIGHT, AARON TODD · 2018 to 2019
$430k
Developmental exposure to polyaromatic hydrocarbons alters functional capacities in metabolism at the host-gut microbiome interface changing susceptibility to chronic disease onsetR56ES030220 · NIEHS · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI WRIGHT, AARON TODD · 2019 to 2019
$170k
NIEHS NIH HHS P42 ES016465NIEHS NIH HHS R21 ES029319NIEHS NIH HHS R56 ES030220
6 · The paper itself

Abstract

The gut microbiome is a key contributor to xenobiotic metabolism. Polycyclic aromatic hydrocarbons (PAHs) are an abundant class of environmental contaminants that have varying levels of carcinogenicity depending on their individual structures. Little is known about how the gut microbiome affects the rates of PAH metabolism. This study sought to determine the role that the gut microbiome has in determining the various aspects of metabolism in the liver, before and after exposure to two structurally different PAHs, benzo[

Indexed as

Gastrointestinal MicrobiomePolycyclic Aromatic HydrocarbonsAnimalsBenzo(a)pyreneMicePyrenesXenobiotics1-nitropyreneBenzo(a)pyrenePolycyclic Aromatic HydrocarbonsPyrenesXenobiotics

Identifiers

PMID35347982
PMCPMC9878584
OpenAlexW4220903529

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.