Evidence map›Paper›PMID 35347916›Full record

SynthesisZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2021

Risk factors for lateral cervical lymph node metastasis in medullary thyroid carcinoma.

Fan Wu, Tianhan Zhou, Kaining Lu, Ting Pan, Yeqin Ni, Lingqian Zhao, Kecheng Jiang, Yu Zhang, Dingcun Luo

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Fan Wu1. The Fourth Clinical Medicine College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Tianhan Zhou1. The Fourth Clinical Medicine College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Kaining Lu2. Department of Surgical Oncology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Ting Pan1. The Fourth Clinical Medicine College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Yeqin Ni2. Department of Surgical Oncology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Lingqian Zhao1. The Fourth Clinical Medicine College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Kecheng Jiang1. The Fourth Clinical Medicine College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Yu Zhang2. Department of Surgical Oncology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Dingcun Luo2. Department of Surgical Oncology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Zhejiang Chinese Medical University · CNHangzhou First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

: To investigate risk factors of lateral cervical lymph node metastasis (LLNM) in patients with medullary thyroid carcinoma (MTC). : Published studies regarding clinicopathological factors of LLNM in MTC were searched in PubMed, Web of Science, Embase, Cochrane library, Wanfang date and CNKI. Statistical analysis was performed using Stata 14.0 software. The mean and standard deviation from the sample size, range, median, and interquartile range was estimated. Odds ratio () or standard mean difference () with 95% confidence interval () of related factors were analyzed by fixed/random-effects models. Egger's test and Begg's test were applied to assess the publication bias of the literature. This study was registered with PROSPERO (CRD42021254955). : Fifteen studies involving 1424 patients were included in the analysis, among whom 543 cases had LLNM (38.13%). Meta-analysis revealed that an increased risk of LLNM was associated with male gender (1.64, 95%: 1.29-2.09, 4.06, 0.01), tumor diameter≥1cm (5.09, 95%: 2.43-10.67, 4.31, 0.01), multifocality (2.55, 95%: 1.79-3.61, 5.22, 0.01), capsule invasion (7.80, 95%: 4.84-12.55, 8.46, 0.01), extracapsular extension (9.46, : 5.66-15.81, 8.58, 0.01), cervical central lymph node metastasis (23.58, : 9.44-58.87, 6.77, 0.01), elevated preoperative calcitonin (1.17,95%: 0.67-1.67, 4.56, 0.01), spiculated margin on ultrasonography (4.32, 95%: 2.43-7.68, 4.99, 0.01), irregular shape on ultrasonography (6.81, : 3.64-12.73, 6.01, 0.01); while age ≥ 45 years (=1.22, 95%: 0.65-2.29, 0.62, >0.05), elevated preoperative carcinoembryonic antigen (0.95, : -0.48-2.38, 1.30, >0.05) and calcification on ultrasonography (1.28, 95%: 0.75-2.18, 0.92, >0.05) were not associated with LLNM. : Male gender, tumor diameter≥multifocality, capsule invasion, extracapsular extension, central lymph node metastasis, elevated preoperative calcitonin, spiculated margin and irregular shape on ultrasonography are risk factors for LLNM in MTC, when these clinical and ultrasonic features are present, lateral neck lymph node dissection is recommended.

Indexed as

Carcinoma, NeuroendocrineThyroid NeoplasmsHumansLymphatic MetastasisLymph NodesMaleMiddle AgedRisk FactorsClinical characteristicsLateral cervical lymph node metastasisMedullary thyroid carcinomaMeta-analysisRisk factorUltrasonic tomography

Identifiers

PMID35347916
PMCPMC8931621
OpenAlexW4225843105

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.