ArticleInternational journal for numerical methods in biomedical engineering2022
A digital twin for simulating the vertebroplasty procedure and its impact on mechanical stability of vertebra in cancer patients.
Article in International journal for numerical methods in biomedical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Dynamic behavior of the nucleus pulposus within the intervertebral disc loading: a systematic review and meta-analysis exploring the concept of dynamic disc model.Frontiers in bioengineering and biotechnology · 2025Pooled it
- Empowering surgeons with integrated synthetic data: solutions for mastering complex clinical scenarios.NPJ digital medicine · 2026Review
- A Computational Multiscale Framework for Bone Remodeling: Coupling Apparent Density Evolution and Microscale Shape Optimization.International journal for numerical methods in biomedical engineering · 2025Article
- A scoping review of human digital twins in healthcare applications and usage patterns.NPJ digital medicine · 2025Article
- Current progress of digital twin construction using medical imaging.Journal of applied clinical medical physics · 2025Review
- Medical digital twins: enabling precision medicine and medical artificial intelligence.The Lancet. Digital health · 2025Review
- Advantages of digital twin technology in orthopedic trauma Surgery - Exploring different clinical use cases.Scientific reports · 2025Article
- Digital twins for the era of personalized surgery.NPJ digital medicine · 2025Review
- From virtual to reality: innovative practices of digital twins in tumor therapy.Journal of translational medicine · 2025Review
- Digital twin assisted surgery, concept, opportunities, and challenges.NPJ digital medicine · 2025Review
- Digital Twins for Clinical and Operational Decision-Making: Scoping Review.Journal of medical Internet research · 2025Article
- Can digital twin technology revolutionize public health emergency management? Insights from the PPRR framework.Frontiers in public health · 2025Article
- Article
- Definitions and Characteristics of Patient Digital Twins Being Developed for Clinical Use: Scoping Review.Journal of medical Internet research · 2024Article
- Digital twins: a new paradigm in oncology in the era of big data.ESMO real world data and digital oncology · 2024Review
- Evolution of digital twins in precision health applications: a scoping review study.Research square · 2024Article
- Rheological Analysis and Evaluation of Measurement Techniques for Curing Poly(Methyl Methacrylate) Bone Cement in Vertebroplasty.ACS biomaterials science & engineering · 2024Article
- Digital twins for health: a scoping review.NPJ digital medicine · 2024Article
- Artificial intelligence across oncology specialties: current applications and emerging tools.BMJ oncology · 2024Review
- Unlocking the potentials of digital twins for optimal healthcare delivery in Africa.Oxford open digital health · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present the application of ReconGAN, introduced in a previous study, for simulating the vertebroplasty (VP) operation and its impact on the fracture response of a vertebral body. ReconGAN consists of a Deep Convolutional Generative Adversarial Network (DCGAN) and a finite element based shape optimization algorithm to virtually reconstruct the trabecular bone microstructure. The VP procedure involves injecting shear-thinning liquid bone cement through a needle in the trabecular region to reinforce a diseased or fractured vertebra. To simulate this treatment modality, computational fluid dynamics (CFD) is employed to predict the morphology of the injected cement within the bone microstructure. A power-law equation is utilized to characterize the non-Newtonian shear-thinning behavior of the polymethyl methacrylate (PMMA) bone cement during injection simulations. The CFD model is coupled with the level-set method to simulate the motion of the interface separating bone cement and bone marrow. After predicting the cement morphology, a data co-registration algorithm is employed to transform the CFD model to a high-fidelity continuum damage mechanics (CDM) finite element model of the augmented vertebra for predicting the fracture response. A feasibility study is presented to demonstrate the ability of this CFD-CDM framework to investigate the effect of VP on the mechanical integrity of the vertebral body in a cancer patient with a lytic metastatic tumor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.