ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2023
Association of life-course traumatic brain injury with dementia risk: A nationwide twin study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Neuropathology in chronic traumatic encephalopathy: a systematic review of comparative post-mortem histology literature.Acta neuropathologica communications · 2022Pooled it
- Traumatic Brain Injury and the Road to Alzheimer's Disease.Biomedicines · 2026Review
- Traumatic brain injury and risk of early-onset dementia: A population-based cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Traumatic Brain Injury and Endocytosis: Reduced Rodent Hippocampal Endocytosis Proteins and Human Clathrin Light Chain Polymorphisms Are Associated with Impaired Neurological Outcomes After TBI.Molecular neurobiology · 2026Article
- Trajectory of depression occurrence before, during, and after dementia diagnosis: A population-based study.Translational psychiatry · 2026Article
- Associations between traumatic brain injury and the prevalence of Alzheimer's disease dementia and behavioral and psychological symptoms of dementia: A retrospective cohort study.The journal of prevention of Alzheimer's disease · 2026Article
- Rate of incident dementia and care needs among older adults with new traumatic brain injury: a population-based cohort study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025Article
- Single episode of moderate to severe traumatic brain injury leads to chronic neurological deficits and Alzheimer's-like pathological dementia.GeroScience · 2024Article
- The Association Between Traumatic Brain Injury and the Risk of Cognitive Decline: An Umbrella Systematic Review and Meta-Analysis.Brain sciences · 2024Review
- Brain Injury and Neurodegeneration: Molecular, Functional, and Translational Approach 2.0.Biomedicines · 2024Article
- Associations Between Traumatic Brain Injury and Cognitive Decline Among Older Male Veterans: A Twin Study.Neurology · 2023Article
- Association of life-course traumatic brain injury with dementia risk: A nationwide twin study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Injurious falls before, during and after dementia diagnosis: a population-based study.Age and ageing · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe impact of life-course traumatic brain injury (TBI) on dementia is unclear.
methodsWithin the Swedish Twin Registry (STR), 35,312 dementia-free twins were followed for up to 18 years. TBI history was identified via medical records. Data were analyzed using generalized estimating equation (GEE) and conditional logistic regression.
resultsIn multi-adjusted GEE models, the odds ratio (OR, 95% confidence interval [CI]) of dementia was 1.27 (1.03-1.57) for TBI at any age, 1.55 (1.04-2.31) for TBI at 50 to 59 years, and 1.67 (1.12-2.49) for TBI at 60 to 69 years. Cardiometabolic diseases (CMDs) increased dementia risk associated with TBI at age 50 to 69 years. The ORs in GEE and conditional logistic regression did not differ significantly (P = .37). DISCUSSION: TBI, especially between ages 50 and 69 years, is associated with an increased risk of dementia, and this is exacerbated among people with CMDs. Genetic and early-life environmental factors may not account for the TBI-dementia association.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.