ArticleActa physiologica (Oxford, England)2022
Extreme duration exercise affects old and younger men differently.
Article in Acta physiologica (Oxford, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Association between "cluster of differentiation 36 (CD36)" and adipose tissue lipolysis during exercise training: a systematic review.Frontiers in physiology · 2023Pooled it
- Musculoskeletal (Mal)adaptations in Response to a > 30 000-km Running Challenge.Journal of cachexia, sarcopenia and muscle · 2026Article
- The Divergent Effects of Nicotinamide Riboside and High-Intensity Exercise Training on Skeletal Muscle Epigenetic Aging.Aging cell · 2026Article
- Skeletal muscle proteomics links mitochondrial abundance with peak fat oxidation in physically active young males.The Journal of physiology · 2026Article
- Cardiac Effects of Prolonged Endurance Exercise in Young and Older Athletes.Scandinavian journal of medicine & science in sports · 2025Article
- A framework of biomarkers for skeletal muscle aging: a consensus statement by the Aging Biomarker Consortium.Life medicine · 2024Article
- Ultra-Cycling- Past, Present, Future: A Narrative Review.Sports medicine - open · 2024Review
- Effect of repeated prolonged exercise on liver fat content and visceral adipose tissue in well-trained older men.Scandinavian journal of medicine & science in sports · 2024Article
- Genotypic and Allelic Distribution of theGenes · 2024Article
- Physical activity impacts resting skeletal muscle myosin conformation and lowers its ATP consumption.The Journal of general physiology · 2023Article
- FAT/CD36 Participation in Human Skeletal Muscle Lipid Metabolism: A Systematic Review.Journal of clinical medicine · 2022Review
- Extreme duration exercise affects old and younger men differently.Acta physiologica (Oxford, England) · 2022Article
Corrections and comments
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Authors and funding
22 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AIM &
methodsExtreme endurance exercise provides a valuable research model for understanding the adaptive metabolic response of older and younger individuals to intense physical activity. Here, we compare a wide range of metabolic and physiologic parameters in two cohorts of seven trained men, age 30 ± 5 years or age 65 ± 6 years, before and after the participants travelled ≈3000 km by bicycle over 15 days.
resultsOver the 15-day exercise intervention, participants lost 2-3 kg fat mass with no significant change in body weight. V̇O
conclusionIn summary, these data suggest that older but not younger individuals experience a negative adaptive response affecting cardiovascular function in response to extreme endurance exercise, while a positive response to the same exercise intervention is observed in peripheral tissues in younger and older men. The results also suggest that the adaptive thresholds differ in younger and old men, and this difference primarily affects central cardiovascular functions in older men after extreme endurance exercise.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.