ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2023
High lifelong cognitive reserve prolongs disability-free survival: The role of cognitive function.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 16 citations in OpenAlex.
- A lifespan perspective on cognitive reserve and risk for dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Relation of Cognitive Reserve Indicator to Heart Disease and Cardiac Structure and Function: A Large Community-Based Longitudinal Study.Journal of the American Heart Association · 2024Article
- Influence of cognitive reserve on risk of depression and subsequent dementia: A large community-based longitudinal study.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Association of Motor Function With Cognitive Trajectories and Structural Brain Differences: A Community-Based Cohort Study.Neurology · 2023Article
- High lifelong cognitive reserve prolongs disability-free survival: The role of cognitive function.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Toward harmonization of strategies for investigating lucidity in AD/ADRD: A preliminary research framework.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
introductionThe association between cognitive reserve (CR) and survival with independence is unknown. We examined whether lifelong CR accumulation is associated with disability-free survival and explored the extent to which cognitive function mediates this association.
methodsWithin the Rush Memory and Aging Project, 1633 dementia- and disability-free participants were followed annually for up to 22 years. Lifelong CR including education, early-/mid-/late-life cognitive activities, and late-life social activity was assessed and tertiled.
resultsCR score was dose-dependently associated with disability/death (hazard ratio [HR] 0.96, 95% confidence interval [CI] 0.93-0.99). Compared to low CR, the HR (95% CI) of disability/death was 0.82 (0.70-0.95) for high CR. The median disability-free survival time was prolonged by 0.99 (95% CI 0.28-1.71) years for participants with high CR. Cognitive function mediated 35.7% of the association between CR and disability-free survival. DISCUSSION: High lifelong CR was associated with prolonged disability-free survival. Cognitive function mediates about one-third of this association. Our findings underscore the importance of CR for healthy aging.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.