Evidence map›Paper›PMID 35347750›Full record

ArticleStatistics in medicine2022

Deep learning for the dynamic prediction of multivariate longitudinal and survival data.

Jeffrey Lin, Sheng Luo

Abstract read
In one paragraph

Article in Statistics in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. A Framework for the Estimation of Quality-Adjusted Life-Years Using Joint Models of Longitudinal and Survival Data.Medical decision making : an international journal of the Society for Medical Decision Making · 2026
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  5. Reduction techniques for survival analysis.Lifetime data analysis · 2026
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  13. tdCoxSNN: Time-dependent Cox survival neural network for continuous-time dynamic prediction.Journal of the Royal Statistical Society. Series C, Applied statistics · 2025
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  20. Deep learning models to predict primary open-angle glaucoma.Stat (International Statistical Institute) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jeffrey LinDepartment of Biostatistics and Data Science, The University of Texas Health Science Center at Houston, Houston, Texas, USA.ORCID 0000-0003-0180-0117
Sheng LuoDepartment of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina, USA.ORCID 0000-0003-4214-5809

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
National Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8M
Resource Core 3 - Metabolomics CoreP30AG028716 · NIA · DUKE UNIVERSITY · PI Sarah B. Peskoe · 2006 to 2026
$24.6M
Research Education Component CoreP30AG072958 · NIA · DUKE UNIVERSITY · PI GWENN A GARDEN, Heather E. Whitson · 2021 to 2026
$24.1M
Integrative modeling and dynamic prediction of Alzheimer's diseaseR01AG064803 · NIA · DUKE UNIVERSITY · PI LUO, SHENG · 2020 to 2024
$2.3M
NIA NIH HHS P30 AG028716NIA NIH HHS P30AG028716NIA NIH HHS P30 AG072958NIA NIH HHS P30AG072958NIA NIH HHS R01 AG064803NIA NIH HHS R01AG064803NIA NIH HHS U01 AG024904NIA NIH HHS U24 AG072122
6 · The paper itself

Abstract

The joint model for longitudinal and survival data improves time-to-event predictions by including longitudinal outcome variables in addition to baseline covariates. However, in practice, joint models may be limited by parametric assumptions in both the longitudinal and survival submodels. In addition, computational difficulties arise when considering multiple longitudinal outcomes due to the large number of random effects to be integrated out in the full likelihood. In this article, we discuss several recent machine learning methods for incorporating multivariate longitudinal data for time-to-event prediction. The presented methods use functional data analysis or convolutional neural networks to model the longitudinal data, both of which scale well to multiple longitudinal outcomes. In addition, we propose a novel architecture based on the transformer neural network, named TransformerJM, which jointly models longitudinal and time-to-event data. The prognostic abilities of each model are assessed and compared through both simulation and real data analysis on Alzheimer's disease datasets. Specifically, the models were evaluated based on their ability to dynamically update predictions as new longitudinal data becomes available. We showed that TransformerJM improves upon the predictive performance of existing methods across different scenarios.

Indexed as

Alzheimer DiseaseDeep LearningHumansMachine LearningNeural Networks, ComputerPrognosisAlzheimer's diseasefunctional data analysisjoint modelpersonalized medicinetemporal convolutionstransformer neural network

Identifiers

PMID35347750
PMCPMC9232978

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.