SynthesisHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2022
Serum Malondialdehyde Levels in Hypertensive Patients: A Non-invasive Marker of Oxidative Stress. A Systematic Review and Meta-analysis.
Synthesis in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Redox Response in Postoperative Metabolic and Bariatric Surgery: New Insights into Cardiovascular Risk Markers.Nutrients · 2025Article
- Assessment of Residual Oxidative Stress in Patients with Well-Controlled Hypertension: A Pilot Cross-Sectional Study.Medical sciences (Basel, Switzerland) · 2025Article
- The Dual Role of Oxidative Stress in Atherosclerosis and Coronary Artery Disease: Pathological Mechanisms and Diagnostic Potential.Antioxidants (Basel, Switzerland) · 2025Review
- Carbonyl reductase 1: a novel regulator of blood pressure in Down syndrome.Bioscience reports · 2025Article
- Depression and anxiety, peripheral blood inflammatory factors, and stress levels on therapeutic outcomes in patients with chronic wounds.World journal of psychiatry · 2024Article
- The Role of Oxidative Stress and Antioxidants in Cardiovascular Comorbidities in COPD.Antioxidants (Basel, Switzerland) · 2023Review
- The influence of vitamin D supplementation and strength training on health biomarkers and chromosomal damage in community-dwelling older adults.Redox biology · 2023Article
- Serum malondialdehyde-modified low-density lipoprotein level is a risk factor for peripheral artery disease in patients with stage 3 to 5 chronic kidney disease.Tzu chi medical journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPrevious analyses have reported a higher malondialdehyde (MDA) serum level in hypertensive patients (HTs) compared to normotensive subjects (NTs).
aimWe performed a systematic review and meta-analysis of these studies to offer a comprehensive information on this issue.
methodsThe PubMed, EMBASE and Web of Science databases were analysed to locate English-language articles published from January 1, 2000 up to January 1 2021. Studies were identified using the following MeSH terms: "Malondialdehyde" AND "Arterial hypertension". The difference of MDA serum levels between HTs and NTs was expressed as standardized mean difference (SMD) with 95% CI using a random-effect model.
resultsA total of of 4102 patients (2158 HTs and 1944 NTs, mean age 52.7 and 48.0 years, respectively) were included in 17 studies. Pooled mean MDA serum levels in HTs and NTs were 4.91 [standard error (SE): 0.34, 95% CI 4.23-5.59)] and 3.43 [SE 0.15, 95% CI 3.18-3.78] nmol/L, respectively. The SMD between HTs and NTs was 3.23 nmol/L (95% CI 2.54-3.92; Z-score for overall effect: 9.17, p < 0.0001, I
conclusionsAmong patients with HTs, serum MDA appears to have the greatest potential as non-invasive biomarkers of oxidative stress and endothelial dysfunction (ED).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.