Evidence map›Paper›PMID 35347503›Full record

ArticleClinical and experimental medicine2023

Combination of IL-34 and AFP improves the diagnostic value during the development of HBV related hepatocellular carcinoma.

Kehui Liu, Yezhou Ding, Yun Wang, Qingqing Zhao, Lei Yan, Jingdong Xie, Yunye Liu, Qing Xie, Wei Cai, Shisan Bao and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Clinical and experimental medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review: Detection of Cancer Biomarkers from a Clinical Perspective.International journal of molecular sciences · 2025
    Review
  3. Article
  4. Article
  5. Review
  6. [Expression of interleukin-34 in tongue squamous cell carcinoma and its clinical implications].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
    Article
  7. Article
  8. Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Kehui Liu *Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Yezhou Ding *Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Yun Wang *Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Qingqing ZhaoDepartment of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Lei YanDepartment of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Jingdong XieDepartment of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Yunye LiuDepartment of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Qing XieDepartment of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Wei CaiDepartment of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. carieyc@hotmail.com.
Shisan BaoDepartment of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. profbao@hotmail.com.
Hui WangDepartment of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. wanghuirj@163.com.ORCID http://orcid.org/0000-0002-5285-7917
Shanghai Jiao Tong University · CN

Funding

National Natural Science Foundation of China 81570560National Science and Technology Major Project 2014ZX10005001National Science and Technology Major Project 2018ZX10205504-001-002Shanghai Municipal Hospitals project: Improving Clinical Skills of Major Diseases 16CR1026BShanghai Municipal Key Clinical Specialty Infectious diseaseShanghai Municipal Key Clinical Specialty YW20190002Technology Supporting Project of the Science and Technology Commission Shanghai Municipality 16411960300The Shanghai key project of Integrated Traditional Chinese and Western Medicine ZY (2018-2020)-FWTX-3001
6 · The paper itself

Abstract

IL-34 involves in host immunity regulated carcinogenesis. Alpha-fetoprotein (AFP) is related to the development of HCC. We explored if combination of IL-34 and APF could improve the diagnostic value in HBV related hepatocellular carcinoma (HBV-HCC). Serum was obtained from HBV patients or healthy control. Liver tissue was obtained from liver biopsy in CHB, HBV related cirrhosis patients or curative resection in HBV-HCC patients. Serum IL-34 and MCSF, or intrahepatic IL-34, MCSF and CD68

Indexed as

Carcinoma, HepatocellularLiver Neoplasmsalpha-FetoproteinsBiomarkers, TumorDNA, ViralHepatitis B virusHumansLiver CirrhosisReproducibility of Resultsalpha-FetoproteinsBiomarkers, TumorDNA, ViralAlpha-fetoproteinDiagnostic biomarkerHBV related HCCIL-34

Identifiers

PMID35347503
PMCPMC10224837
OpenAlexW4225881019

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.