ArticleNature ecology & evolution2022
Intra- and interpopulation transposition of mobile genetic elements driven by antibiotic selection.
Article in Nature ecology & evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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47 citing papers in PubMed, 95 citations in OpenAlex.
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- Environmental Biofilms in Livestock Production Systems: Reservoirs of Pathogens and Antimicrobial Resistance.Life (Basel, Switzerland) · 2026Review
- Integrating theory and machine learning to reveal determinants of plasmid copy number.Nature communications · 2026Article
- How Glyphosate and Its Derivatives Influence Antimicrobial Resistance Emergence and Transmission: A One Health Perspective.Antibiotics (Basel, Switzerland) · 2026Review
- Plasmids promote antimicrobial resistance through insertion sequence-mediated gene inactivation.Nature microbiology · 2026Article
- Dietary copper-driven colonic dysbiosis mediates oxidative stress and butyrate deficiency to facilitate the spread of resistome in pigs.NPJ biofilms and microbiomes · 2026Article
- Bovine Mastitis Therapy at a Crossroads: Pharmacokinetic Barriers, Biofilms, Antimicrobial Resistance, and Emerging Solutions.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Substrate toxicity drives successive range expansions opposing spatial intermixing in cross-feeding consortia.ISME communications · 2026Article
- Evolutionary selection of trimethoprim-resistantScience advances · 2025Article
- The extended mobility of plasmids.Nucleic acids research · 2025Review
- Scaling laws of bacterial and archaeal plasmids.Nature communications · 2025Article
- Two novel trimethoprim resistance genes,Antimicrobial agents and chemotherapy · 2025Article
- Spatial entropy drives the maintenance and dissemination of transferable plasmids.Molecular systems biology · 2025Article
- Transposon-plasmid nesting enables fast response to fluctuating environments.bioRxiv : the preprint server for biology · 2025Article
- Population-level amplification of gene regulation by programmable gene transfer.Nature chemical biology · 2025Article
- Genomic and phylogeographical analysis revealed CTX-M-55 producingOne health (Amsterdam, Netherlands) · 2025Article
- A Cross-Sectional Study Assessing Antibiotic Resistance Awareness Among University Students in Samborondón, Greater Guayaquil, Ecuador.Antibiotics (Basel, Switzerland) · 2025Article
- Plant Diversity Reduces the Risk of Antibiotic Resistance Genes in Agroecosystems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
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7 authors at 1 institution in 1 country.
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Abstract
The spread of genes encoding antibiotic resistance is often mediated by horizontal gene transfer (HGT). Many of these genes are associated with transposons, a type of mobile genetic element that can translocate between the chromosome and plasmids. It is widely accepted that the translocation of antibiotic resistance genes onto plasmids potentiates their spread by HGT. However, it is unclear how this process is modulated by environmental factors, especially antibiotic treatment. To address this issue, we asked whether antibiotic exposure would select for the transposition of resistance genes from chromosomes onto plasmids and, if so, whether antibiotic concentration could tune the distribution of resistance genes between chromosomes and plasmids. We addressed these questions by analysing the transposition dynamics of synthetic and natural transposons that encode resistance to different antibiotics. We found that stronger antibiotic selection leads to a higher fraction of cells carrying the resistance on plasmids because the increased copy number of resistance genes on multicopy plasmids leads to higher expression of those genes and thus higher cell survival when facing antibiotic selection. Once they have transposed to plasmids, antibiotic resistance genes are primed for rapid spread by HGT. Our results provide quantitative evidence for a mechanism by which antibiotic selection accelerates the spread of antibiotic resistance in microbial communities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.