ArticleNature communications2022
Genetic variation of macronutrient tolerance in Drosophila melanogaster.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
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- Making Sense of Developmental Kinetics Under High-Sugar Stress: Mathematical Modeling of Phenotypic Plasticity inNutrients · 2026Article
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- Variation in the resource environment affects patterns of seasonal adaptation at phenotypic and genomic levels inEvolution letters · 2025Article
- High-throughput measurement of Drosophila feeding behavior.Cell reports methods · 2025Article
- Review
- Nutritional Trade-Offs inBiology · 2025Article
- Adipocyte-DerivedBiomolecules · 2025Article
- On the use of kinship and familiarity associated social information in mediating Drosophila melanogaster oviposition decisions.PloS one · 2025Article
- Genetic Variation in Trophic Avoidance Behaviour Shows Fruit Flies are Generally Attracted to Bacterial Substrates.Ecology and evolution · 2024Article
- Wnt signaling couples G2 phase control with differentiation during hematopoiesis in Drosophila.Developmental cell · 2024Article
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- TNIK is a conserved regulator of glucose and lipid metabolism in obesity.Science advances · 2023Article
- Nuclear genetic background influences the phenotype of the Drosophila tko25t mitochondrial protein-synthesis mutant.G3 (Bethesda, Md.) · 2023Article
- Nutrigonometry IV: Thales' theorem to measure the rules of dietary compromise in animals.Scientific reports · 2023Article
- Review
- Article
- Dietary regulation in health and disease.Signal transduction and targeted therapy · 2022Review
- Genetic variation of macronutrient tolerance in Drosophila melanogaster.Nature communications · 2022Article
Corrections and comments
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Authors and funding
24 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carbohydrates, proteins and lipids are essential nutrients to all animals; however, closely related species, populations, and individuals can display dramatic variation in diet. Here we explore the variation in macronutrient tolerance in Drosophila melanogaster using the Drosophila genetic reference panel, a collection of ~200 strains derived from a single natural population. Our study demonstrates that D. melanogaster, often considered a "dietary generalist", displays marked genetic variation in survival on different diets, notably on high-sugar diet. Our genetic analysis and functional validation identify several regulators of macronutrient tolerance, including CG10960/GLUT8, Pkn and Eip75B. We also demonstrate a role for the JNK pathway in sugar tolerance and de novo lipogenesis. Finally, we report a role for tailless, a conserved orphan nuclear hormone receptor, in regulating sugar metabolism via insulin-like peptide secretion and sugar-responsive CCHamide-2 expression. Our study provides support for the use of nutrigenomics in the development of personalized nutrition.
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