SynthesisTranslational psychiatry2022
Genetics of age-at-onset in major depression.
Synthesis in Translational psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genetics, epigenetics, and neurobiology of childhood-onset depression: an umbrella review.Molecular psychiatry · 2024Pooled it
- Clinical characteristics indexing genetic differences in bipolar disorder - a systematic review.Molecular psychiatry · 2023Pooled it
- Familial genetic risk for posttraumatic stress disorder: Associations with clinical features.Journal of traumatic stress · 2026Article
- Impaired regional structure-function coupling as novel neurophenotype: mechanistic insights and diagnostic exploration in treatment-resistant depression.Npj mental health research · 2026Article
- Can Psychiatric Genetics Advance Without Incorporating a Life Course Perspective?Biological psychiatry · 2026Review
- The intersection between race/ethnicity and adverse childhood experiences and its association with depression.Social psychiatry and psychiatric epidemiology · 2026Article
- Genetic Signal Augmentation of Childhood-Onset and Treatment-Resistant Major Depression Reveals Distinct Biological Disorders.medRxiv : the preprint server for health sciences · 2026Article
- Association between Cortical Gyrification and Major Depression: Clinical Correlates.Psychopathology · 2026Article
- The Multifaceted Pathophysiology of Major Depressive Disorder: Integrating Neurobiology, Genetics, and Systems-level Perspectives.Current neurovascular research · 2026Review
- Genome-wide association analyses identify distinct genetic architectures for early-onset and late-onset depression.Nature genetics · 2025Article
- Genome-wide association study of adolescent-onset depression.medRxiv : the preprint server for health sciences · 2025Article
- Effects of substituting TV-watching time with physical activities or sleep on incident major depression. Results from the lifelines cohort study.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- The causal role of male pubertal timing for the development of externalizing and internalizing traits: results from Mendelian randomization studies.Psychological medicine · 2025Article
- Changes in dementia risk along with onset age of depression: a longitudinal cohort study of elderly depressed patients.BMC psychiatry · 2025Article
- Childhood trajectories of emotional and behavioral difficulties are related to polygenic liability for mood and anxiety disorders.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- The genetics of severe depression.Molecular psychiatry · 2025Review
- Long-term physical health conditions and youth anxiety and depression: Is there a causal link?Psychological medicine · 2025Article
- The impact of tea consumption on the risk of depression: A Mendelian randomization and Bayesian weighting algorithm study.Asia Pacific journal of clinical nutrition · 2024Article
- Enhancing Transcriptomic Insights into Neurological Disorders Through the Comparative Analysis of Shapley Values.Current issues in molecular biology · 2024Article
- A unified framework for estimating country-specific cumulative incidence for 18 diseases stratified by polygenic risk.Nature communications · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Major depression (MD) is a complex, heterogeneous neuropsychiatric disorder. An early age at onset of major depression (AAO-MD) has been associated with more severe illness, psychosis, and suicidality. However, not much is known about what contributes to individual variation in this important clinical characteristic. This study sought to investigate the genetic components underlying AAO-MD. To investigate the genetics of AAO-MD, we conducted a genome-wide association meta-analysis of AAO-MD based on self-reported age of symptoms onset and self-reported age at first diagnosis from the UK Biobank cohort (total N = 94,154). We examined the genetic relationship between AAO-MD and five other psychiatric disorders. Polygenic risk scores were derived to examine their association with five psychiatric outcomes and AAO-MD in independent sub-samples. We found a small but significant SNP-heritability (~6%) for the AAO-MD phenotype. No SNP or gene reached SNP or gene-level significance. We found evidence that AAO-MD has genetic overlap with MD risk ([Formula: see text] = -0.49). Similarly, we found shared genetic risks between AAO-MD and autism-spectrum disorder, schizophrenia, bipolar disorder, and anorexia nervosa ([Formula: see text] range: -0.3 to -0.5). Polygenic risk scores for AAO-MD were associated with MD, schizophrenia, and bipolar disorder, and AAO-MD was in turn associated with polygenic risk scores derived from these disorders. Overall, our results indicate that AAO-MD is heritable, and there is an inverse genetic relationship between AAO-MD and both major depression and other psychiatric disorders, meaning that SNPs associated with earlier age at onset tend to increase the risk for psychiatric disorders. These findings suggest that the genetics of AAO-MD contribute to the shared genetic architecture observed between psychiatric disorders.
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