Evidence map›Paper›PMID 35347062›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2022

Anesthetic Preconditioning of Traumatic Brain Injury Is Ineffective in a Drosophila Model of Obesity.

Dena Johnson-Schlitz, Julie A Fischer, Hannah J Schiffman, Amanda R Scharenbrock, Zachariah P G Olufs, David A Wassarman, Misha Perouansky

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Quantitative genetics of trauma induced mortality inbioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Dena Johnson-SchlitzDepartment of Anesthesiology (D.J.-S., J.A.F., H.J.S., A.R.S., Z.P.G.O., M.P.) and Department of Medical Genetics (D.A.W.), University of Wisconsin-Madison, Madison, Wisconsin.
Julie A FischerDepartment of Anesthesiology (D.J.-S., J.A.F., H.J.S., A.R.S., Z.P.G.O., M.P.) and Department of Medical Genetics (D.A.W.), University of Wisconsin-Madison, Madison, Wisconsin.
Hannah J SchiffmanDepartment of Anesthesiology (D.J.-S., J.A.F., H.J.S., A.R.S., Z.P.G.O., M.P.) and Department of Medical Genetics (D.A.W.), University of Wisconsin-Madison, Madison, Wisconsin.
Amanda R ScharenbrockDepartment of Anesthesiology (D.J.-S., J.A.F., H.J.S., A.R.S., Z.P.G.O., M.P.) and Department of Medical Genetics (D.A.W.), University of Wisconsin-Madison, Madison, Wisconsin.
Zachariah P G OlufsDepartment of Anesthesiology (D.J.-S., J.A.F., H.J.S., A.R.S., Z.P.G.O., M.P.) and Department of Medical Genetics (D.A.W.), University of Wisconsin-Madison, Madison, Wisconsin.
David A WassarmanDepartment of Anesthesiology (D.J.-S., J.A.F., H.J.S., A.R.S., Z.P.G.O., M.P.) and Department of Medical Genetics (D.A.W.), University of Wisconsin-Madison, Madison, Wisconsin.
Misha PerouanskyDepartment of Anesthesiology (D.J.-S., J.A.F., H.J.S., A.R.S., Z.P.G.O., M.P.) and Department of Medical Genetics (D.A.W.), University of Wisconsin-Madison, Madison, Wisconsin mperouansky@wisc.edu.
University of Wisconsin–Madison · US

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
TBI and aging in a Drosophila modelRF1NS114359 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI WASSARMAN, DAVID · 2019 to 2019
$2.8M
NCATS NIH HHS UL1 TR002373NINDS NIH HHS RF1 NS114359
6 · The paper itself

Abstract

We tested the hypothesis that obesity influences the pharmacodynamics of volatile general anesthetics (VGAs) by comparing effects of anesthetic exposure on mortality from traumatic brain injury (TBI) in lean and obese

Indexed as

Anesthetics, InhalationBrain Injuries, TraumaticIsofluraneAnimalsDrosophilaDrosophila melanogasterObesitySevofluraneAnesthetics, InhalationIsofluraneSevoflurane

Identifiers

PMID35347062
PMCPMC9190232
OpenAlexW4220787104

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.