ArticleeNeuro
White-Matter Integrity and Working Memory: Links to Aging and Dopamine-Related Genes.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Explaining cognitive function in multiple sclerosis through networks of grey and white matter features: a joint independent component analysis.Journal of neurology · 2025Article
- Exploring the dynamic interplay between learning and working memory within various cognitive contexts.Frontiers in behavioral neuroscience · 2024Article
- The neurocognitive correlates of DTI indicators of white matter disorganization in pediatric moderate-to-severe traumatic brain injury.Frontiers in human neuroscience · 2024Article
- Deciphering the causal relationship between blood pressure and regional white matter integrity: A two-sample Mendelian randomization study.Journal of neuroscience research · 2023Article
- EngAge - A metacognitive intervention to supplement working memory training: A feasibility study in older adults.Aging brain · 2023Article
- Structural connectivity of the human olfactory network and its relation to aging and olfactory function.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
5 authors.
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Abstract
Working memory, a core function underlying many higher-level cognitive processes, requires cooperation of multiple brain regions. White matter refers to myelinated axons, which are critical to interregional brain communication. Past studies on the association between white-matter integrity and working memory have yielded mixed findings. Using voxelwise tract-based spatial statistics analysis, we investigated this relationship in a sample of 328 healthy adults from 25 to 80 years of age. Given the important role of dopamine (DA) in working-memory functioning and white matter, we also analyzed the effects of dopamine-related genes on them. There were associations between white-matter integrity and working memory in multiple tracts, indicating that working-memory functioning relies on global connections between different brain areas across the adult life span. Moreover, a mediation analysis suggested that white-matter integrity contributes to age-related differences in working memory. Finally, there was an effect of the
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Registered trials
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