Evidence map›Paper›PMID 35346960›Full record

ArticleeNeuro

Cyclic, Condition-Independent Activity in Primary Motor Cortex Predicts Corrective Movement Behavior.

Adam G Rouse, Marc H Schieber, Sridevi V Sarma

Abstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Identifying Distinct Neural Features between the Initial and Corrective Phases of Precise Reaching Using AutoLFADS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Adam G RouseDepartment of Neurosurgery, Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160 arouse@kumc.edu.ORCID 0000-0003-3785-1442
Marc H SchieberDepartment of Neurology, Department of Neuroscience, Del Monte Institute for Neuroscience, University of Rochester Medical Center, Rochester, NY 14642.ORCID 0000-0002-4315-8161
Sridevi V SarmaDepartment of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218.

Funding

Observation of PerformanceR01NS102343 · NINDS · UNIVERSITY OF ROCHESTER · PI SCHIEBER, MARC H · 2018 to 2022
$2.5M
Neural Encoding of Motor Precision for Advancing Brain-Machine InterfacesR00NS101127 · NINDS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ROUSE, ADAM G · 2020 to 2022
$747k
NINDS NIH HHS R00 NS101127NINDS NIH HHS R01 NS102343
6 · The paper itself

Abstract

Reaching movements are known to have large condition-independent (CI) neural activity and cyclic neural dynamics. A new precision center-out task was performed by rhesus macaques to test the hypothesis that cyclic, CI neural activity in the primary motor cortex (M1) occurs not only during initial reaching movements but also during subsequent corrective movements. Corrective movements were observed to be discrete with time courses and bell-shaped speed profiles similar to the initial movements. CI cyclic neural trajectories were similar and repeated for initial and each additional corrective submovement. The phase of the cyclic CI neural activity predicted the time of peak movement speed more accurately than regression of instantaneous firing rate, even when the subject made multiple corrective movements. Rather than being controlled as continuations of the initial reach, a discrete cycle of motor cortex activity encodes each corrective submovement.

Indexed as

Motor CortexAnimalsMacaca mulattaMovementPsychomotor Performancecorrectivemacaquemotormotor cortexprecisionreaching

Identifiers

PMID35346960
PMCPMC9014981

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.