Evidence map›Paper›PMID 35346954›Full record

ArticleBMJ global health2022

Cost-effectiveness analysis of human-centred design for global health interventions: a quantitative framework.

Chen Liu, Jae Hyoung Lee, Amanda J Gupta, Austin Tucker, Chris Larkin, Patricia Turimumahoro, Achilles Katamba, J Lucian Davis, David Dowdy

Abstract read
In one paragraph

Article in BMJ global health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chen Liu *Department of Division of Pulmonary & Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Jae Hyoung Lee *Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA jlee736@jhu.edu.ORCID 0000-0002-6303-086X
Amanda J GuptaDepartment of Health Equity and Social Justice, Johns Hopkins School of Public Health, Baltimore, Maryland, USA.
Austin TuckerDepartment of Population Health Sciences, Harvard University T H Chan School of Public Health, Boston, Massachusetts, USA.
Chris LarkinIDEO.org, Palo Alto, California, USA.
Patricia Turimumahoro *Uganda Tuberculosis Implementation Research Consortium, Makerere University, Kampala, Central, Uganda.ORCID 0000-0003-1910-8559
Achilles KatambaUganda Tuberculosis Implementation Research Consortium, Makerere University, Kampala, Central, Uganda.
J Lucian Davis *Uganda Tuberculosis Implementation Research Consortium, Makerere University, Kampala, Central, Uganda.ORCID 0000-0002-8629-9992
David Dowdy *Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.

Funding

Mobile Health for Implementation of Home-based TB Contact Investigation in UgandaR01AI104824 · NIAID · YALE UNIVERSITY · PI DAVIS, JOHN LUCIAN · 2013 to 2023
$6.7M
NIAID NIH HHS R01 AI104824
6 · The paper itself

Abstract

introductionHuman-centred design (HCD) is a problem-solving approach that is increasingly used to develop new global health interventions. However, there is often a large initial cost associated with HCD, and global health decision-makers would benefit from an improved understanding of the cost-effectiveness of HCD, particularly the trade-offs between the up-front costs of design and the long-term costs of delivering health interventions.

methodsWe developed a quantitative framework from a health systems perspective to illustrate the conditions under which HCD-informed interventions are likely to be cost-effective, taking into consideration five elements: cost of HCD, per-client intervention cost, anticipated number of clients reached, anticipated incremental per-client health benefit (ie, disability-adjusted life years (DALYs) averted) and willingness-to-pay. We evaluated several combinations of fixed and implementation cost scenarios based on the estimated costs of an HCD-informed approach to tuberculosis (TB) contact investigation in Uganda over a 2-year period to illustrate the use of this framework.

resultsThe cost-effectiveness of HCD-informed TB contact investigation in Uganda was estimated to vary from US$8400 (2400 clients reached, lower HCD cost estimate) to US$306 000 per DALY averted (120 clients reached, baseline HCD cost estimate). In our model, cost-effectiveness was improved further when the interventions were expected to have wider reach or higher per-client health benefits.

conclusionHCD can be cost-effective when used to inform interventions that are anticipated to reach a large number of clients, or in which the cost of HCD is smaller relative to the cost of delivering the intervention itself.

Indexed as

Global HealthTuberculosisCost-Benefit AnalysisHumanshealth economicshealth policytuberculosis

Identifiers

PMID35346954
PMCPMC8961136

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.