Evidence map›Paper›PMID 35346219›Full record

ArticleHarm reduction journal2022

How do people who use drugs receiving Opioid Medication Therapy perceive their treatment ? A multicentre study.

Morgane Guillou Landreat, Antoine Dany, Gaelle Challet Bouju, Edouard-Jules Laforgue, J Cholet, Juliette Leboucher, Jean Benoit Hardouin, OPAL Group, Caroline Victorri Vigneau, Marie Grall Bronnec

Registry-linked trialOpen access · goldAbstract readMulticenter Study
In one paragraph

Article in Harm reduction journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01847729 (A Multicenter Study Assessing the Prevalence of Co-addictions in Subjects Receiving Maintenance Treatment for Opiate Dependence. Determination of Clinical and Pharmacological Profil.), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01847729 completednot on this map

A Multicenter Study Assessing the Prevalence of Co-addictions in Subjects Receiving Maintenance Treatment for Opiate Dependence. Determination of Clinical and Pharmacological Profil.

TypeobservationalSponsorNantes University HospitalRan2013 to 2016Enrolled263ConditionsSubstance Use Disorder
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Morgane Guillou LandreatINSERM UMR 1246, SPHERE, Methods in Patient- Centered Outcomes and Health Research, Nantes and Tours Universities, Nantes, France.ORCID 0000-0003-1568-9480
Antoine DanyEA 7479 SPURBO, BREST University, Brest, France.
Gaelle Challet BoujuINSERM UMR 1246, SPHERE, Methods in Patient- Centered Outcomes and Health Research, Nantes and Tours Universities, Nantes, France.
Edouard-Jules LaforgueINSERM UMR 1246, SPHERE, Methods in Patient- Centered Outcomes and Health Research, Nantes and Tours Universities, Nantes, France.
J CholetCHU Nantes, Addictology and Psychiatry Department, Nantes, France.
Juliette LeboucherCHU Nantes, Addictology and Psychiatry Department, Nantes, France.
Jean Benoit HardouinINSERM UMR 1246, SPHERE, Methods in Patient- Centered Outcomes and Health Research, Nantes and Tours Universities, Nantes, France.
OPAL Group
Caroline Victorri VigneauINSERM UMR 1246, SPHERE, Methods in Patient- Centered Outcomes and Health Research, Nantes and Tours Universities, Nantes, France.
Marie Grall BronnecINSERM UMR 1246, SPHERE, Methods in Patient- Centered Outcomes and Health Research, Nantes and Tours Universities, Nantes, France. marie.bronnec@chu-nantes.fr.
Université de Tours · FRCentre d'Investigation Clinique de Nantes · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe resurgence of heroin use and the misuse of pharmaceutical opioids are some of the reasons for a worldwide increase in opioid dependence. Opioid Medication Therapies (OMT) have amply demonstrated their efficacy. From a medical point of view, the main objectives of OMT concern medical and social outcomes, centred on risk reduction and the cessation of opioid use. But patient points of view can differ and few studies have explored opioid-dependent patient viewpoints on their OMT. This variable seems important to consider in a patient-centred approach. The aim of our study was to explore points of view of people who use drugs (PWUD) treated with OMT, in a large multicentre sample.

methodA cross-sectional multicentre study explored the points of view of PWUD with Opioid Use Disorder following OMT. Data regarding the patients' points of view were collected using a self-administered questionnaire developed by the scientific committee of the study. A descriptive analysis and an exploratory factor analysis were performed to explore the structure of items exploring patient viewpoints.

results263 opioid dependent PWUD were included, a majority were men consuming heroin prior to being prescribed OMT. 68% were on methadone, 32% were on buprenorphine. Most PWUD identified a positive impact on their lives, with 92.8% agreeing or strongly agreeing that OMT had changed a lot of things in their lives. The exploratory factor analysis identified three factors: (F1) items related to points of views concerning the objectives and efficacy of OMT; (F2) items related to the legitimacy of OMT as a treatment compared to a drug, (F3) items related to experiences and relationships with OMT.

conclusionPatient viewpoints on efficacy were correlated with the pharmacological benefits of OMT and with the associated psychosocial measures. The implications of OMT in relationships, such as the feeling of being judged, concerned a majority. Points of view were ambivalent concerning the role of OMT as a treatment or as a drug. Involving patient points of view in therapeutic strategies decisions could help enhance positive views among PWUD on OMT and help PWUD towards their recovery.

trial registrationOPAL study was registered: (NCT01847729).

Indexed as

Analgesics, OpioidBuprenorphineCross-Sectional StudiesFemaleHumansMaleMethadoneOpiate Substitution TreatmentAnalgesics, OpioidBuprenorphineMethadone

Identifiers

PMID35346219
PMCPMC8961988
OpenAlexW4221082227

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.