SynthesisNutrition journal2022
Evaluation of the association between maternal folic acid supplementation and the risk of congenital heart disease: a systematic review and meta-analysis.
Synthesis in Nutrition journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- Management of Lithium in Pregnancy and Lactation: An Individualized Approach.Current psychiatry reports · 2026Review
- Biological, dietetic and pharmacological properties of vitamin BNPJ science of food · 2025Review
- Folic acid supplementation on congenital heart disease and its dual character.Current research in pharmacology and drug discovery · 2025Review
- Vitamin D and LC-PUFA and the Presence of Fetal Heart Defects-A Further Part of a Case-Control Study.Nutrients · 2024Article
- Maternal Serum Folate During Pregnancy and Congenital Heart Disease in Offspring.JAMA network open · 2024Article
- Folic Acid and Selected Risk Factors for Fetal Heart Defects-Preliminary Study Results.Nutrients · 2024Article
- Plasma metabolomic and lipidomic profiles accurately classify mothers of children with congenital heart disease: an observational study.Metabolomics : Official journal of the Metabolomic Society · 2024Observational
- Epigenetic Genome Modifications during Pregnancy: The Impact of Essential Nutritional Supplements on DNA Methylation.Nutrients · 2024Review
- Association of Maternal Folate Intake and Offspring MTHFD1 and MTHFD2 Genes with Congenital Heart Disease.Nutrients · 2023Article
- Initiation and duration of folic acid supplementation in preventing congenital malformations.BMC medicine · 2023Article
- Folate Supplementation in Women with Pre-Existing Diabetes.Nutrients · 2023Review
- Sociodemographic Profile Associated with Congenital Heart Disease among Infants Less than 1 Year Old.Research square · 2023Article
- Article
- Sociodemographic profile associated with congenital heart disease among infants <1 year old.Journal of pediatric nursingArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFolic acid (FA), as a synthetic form of folate, has been widely used for dietary supplementation in pregnant women. The preventive effect of FA supplementation on the occurrence and recurrence of fetal neural tube defects (NTD) has been confirmed. Incidence of congenital heart diseases (CHD), however, has been parallelly increasing worldwide. The present study aimed to evaluate whether FA supplementation is associated with a decreased risk of CHD.
methodsWe searched the literature using PubMed, Web of Science and Google Scholar, for the peer-reviewed studies which reported CHD and FA and followed with a meta-analysis. The study-specific relative risks were used as summary statistics for the association between maternal FA supplementation and CHD risk. Cochran's Q and I
resultsMaternal FA supplementation was found to be associated with a decreased risk of CHD (OR = 0.82, 95% CI: 0.72-0.94). However, the heterogeneity of the association was high (P < 0.001, I
conclusionsData from the present study indicate that the heterogeneity of the association between maternal FA supplementation and CHD is high and suggest that the real relationship between maternal FA supplementation and CHD may need to be further investigated with well-designed clinical studies and biological experiments.
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