ArticleBMC infectious diseases2022
Incidence of acute otitis media in children in the United States before and after the introduction of 7- and 13-valent pneumococcal conjugate vaccines during 1998-2018.
Article in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- A Systematic Review and Meta-Analysis of the Efficacy of Antimicrobial Chemoprophylaxis for Recurrent Acute Otitis Media in Children.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2025Pooled it
- Pooled it
- Linking Dispense Data to Electronic Health Orders: Tutorial for Querying Commercial Pharmacy Databases to Support Systemwide Quality Improvement.Journal of medical Internet research · 2026Article
- Healthcare resource utilization and cost of invasive pneumococcal disease, pneumonia, and acute otitis media in commercially and medicaid-insured children by risk group in the United States, 2018 to 2023.Pneumonia (Nathan Qld.) · 2026Article
- Characterising 'Watch and Wait' prescribing patterns in paediatric otitis media using large language models and pharmacy dispense data.BMJ health & care informatics · 2026Article
- Global patterns and demographic drivers of hearing loss attributable to otitis media, 1990-2023.PloS one · 2026Article
- Influence of area-level social vulnerability on all-cause pneumonia, all-cause acute otitis media, and invasive pneumococcal disease incidence among Medicaid-enrolled children.Pneumonia (Nathan Qld.) · 2025Article
- A SNAPpy use of large language models: using large language models to classify treatment plans in pediatric acute otitis media.Journal of the American Medical Informatics Association : JAMIA · 2025Article
- Interventions to Minimize Unnecessary Antibiotic Use for Acute Otitis Media: A Meta-Analysis.Children (Basel, Switzerland) · 2025Review
- Incidence, antimicrobial prescribing practice, and associated healthcare costs of paediatric otorrhoea in primary care in the UK: a longitudinal population study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2025Article
- Characteristics and antimicrobial susceptibility of bacteria causing acute otitis media in children at Vietnam National Children's Hospital: a cross-sectional study.JAC-antimicrobial resistance · 2025Article
- Disparities in invasive pneumococcal disease, pneumonia, and otitis media among US children by comorbidity profile and insurance status.Frontiers in public health · 2025Observational
- A dynamic transmission model for assessing the impact of pneumococcal vaccination in the United States.PloS one · 2025Article
- Clinical and economic burden of otitis media in children under 5 years of age in the United States: A retrospective study.Human vaccines & immunotherapeutics · 2024Article
- ISOM 2023 Research Panel 5: Interventions- Vaccines and prevention, medical and surgical treatment, and impact of COVID-19 pandemic.International journal of pediatric otorhinolaryngology · 2024Review
- Prevalence and Outpatient Clinical Diagnostic Approaches for Common Acute Respiratory Tract Infections in Children Under Five Years of Age: A Cross-Sectional Study.Pediatric health, medicine and therapeutics · 2024Article
- Characterization ofFrontiers in pediatrics · 2024Article
- Pneumococcal Vaccine Breakthrough and Failure in Infants and Children: A Narrative Review.Vaccines · 2023Review
- Antibiotic Resistance ofAntibiotics (Basel, Switzerland) · 2023Article
- Dynamics of Antibiotic Resistance ofAntibiotics (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute otitis media (AOM) is a leading cause of office visits and antibiotic prescriptions in children. Pneumococcal conjugate vaccines were introduced in the USA in 2000 (7-valent, PCV7) and 2010 (13-valent, PCV13). Expanded valency PCVs are currently under development. To describe the impact of PCVs and quantify the residual burden of AOM, this study estimated annual incidence rates (IRs) of AOM and AOM-related complications and surgical procedures in children < 18 years in the USA before and after the introduction of PCV7 and PCV13.
methodsAOM episodes were identified in the IBM MarketScan
resultsIn the commercially insured population, AOM IRs declined between the pre-PCV7 period (1998-1999) and the late PCV13 period (2014-2018) from 1170.1 to 768.8 episodes per 1000 PY for children < 2 years, from 547.4 to 410.3 episodes per 1000 PY in children 2-4 years, and from 115.6 to 91.8 episodes per 1000 PY in children 5-17 years. The interrupted time series analyses indicated significant immediate or gradual decreases in the early PCV7 period (2001-2005), and gradual increases in the late PCV7 period (2006-2009) in children < 2 years; however, crude IRs trended downward in all time periods. In older children, IRs decreased in the early PCV7 and early PCV13 period (2011-2013), but gradually increased in the late PCV7 period. IRs of AOM-related surgical procedures decreased, and IRs of AOM-related complications increased during the study timeframe.
conclusionsAOM disease burden remains high in children of all ages despite overall reductions in AOM IRs during 1998-2018 following the introduction of PCV7 and PCV13. The impact of investigational PCVs on the disease burden of AOM will likely depend on AOM etiology and circulating pneumococcal serotypes.
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