Evidence map›Paper›PMID 35346041›Full record

Trial reportBMC anesthesiology2022

Effectiveness of single loading dose of dexmedetomidine combined with propofol for deep sedation of endoscopic retrograde cholangiopancreatography (ERCP) in elderly patients: a prospective randomized study.

Mo Chen, Yi Sun, Xueyan Li, Chun Zhang, Xiaochen Huang, Yiming Xu, Chengyong Gu

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07384169 (The Impact of Frailty and Different Sedation Techniques on Cognitive Function in Geriatric Colonoscopy Patients), which is not on this map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07384169 completednot on this mapstarted 2023, after this paper: background citation

The Impact of Frailty and Different Sedation Techniques on Cognitive Function in Geriatric Colonoscopy Patients

TypeobservationalSponsorAnkara City Hospital BilkentRan2023 to 2024Enrolled164ConditionsCognition, Sedation, Geriatric Anesthesia, FrailtyArmsPropofol Group, Dexmedetomidine group
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mo Chen *Department of Anesthesiology, Gusu School, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical University, No.242 Guangji Road, Suzhou, Jiangsu, China.
Yi Sun *Department of Anesthesiology, Gusu School, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical University, No.242 Guangji Road, Suzhou, Jiangsu, China.
Xueyan LiDepartment of Anesthesiology, Gusu School, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical University, No.242 Guangji Road, Suzhou, Jiangsu, China.
Chun ZhangDepartment of Anesthesiology, Gusu School, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical University, No.242 Guangji Road, Suzhou, Jiangsu, China.
Xiaochen HuangDepartment of Anesthesiology, Gusu School, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical University, No.242 Guangji Road, Suzhou, Jiangsu, China.
Yiming XuDepartment of Anesthesiology, Gusu School, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical University, No.242 Guangji Road, Suzhou, Jiangsu, China.
Chengyong GuDepartment of Anesthesiology, Gusu School, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical University, No.242 Guangji Road, Suzhou, Jiangsu, China. gcygcy1979@163.com.
Nanjing Medical University · CNSuzhou Municipal Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEndoscopic retrograde cholangiopancreatography (ERCP) is an advanced endoscopic procedure and requires deep sedation. Deep sedation with dexmedetomidine for the respiratory drive preserved has become popular in recent years. However, the use of dexmedetomidine in elderly patients is controversial because its adverse events are more common. The objective of this study was to investigate the effectiveness of a single loading dose of dexmedetomidine combined with propofol for deep sedation of ERCP in elderly patients.

methodsIn this prospective randomized trial, 49 elderly patients undergoing ERCP were randomly allocated to the dexmedetomidine (DEX) or propofol (PRO) groups. The single loading dose of dexmedetomidine was set at 0.5 μg/kg at the start of anesthesia induction and loading for 10 min. The primary outcome was the cumulative dose of propofol. Secondary outcomes included time to awake, the frequency of airway interventions, and hemodynamics.

resultsThe intraoperative cumulative dose of propofol was lower in the DEX group (111.0 ± 12.6 μg/kg/min) than the PRO group (143.7 ± 23.4 μg/kg/min) (P < 0.001). There was no statistically significant difference in the time to awake between the two groups. The incidence of artificial airway interventions and hypotension in the PRO group (36%, 60%) were significantly higher than those in the DEX group (4.2%, 16.7%) (P = 0.011, P = 0.003, respectively). In addition, the occurrence of bradycardia increased significantly in the DEX group (58.3%) compared with the PRO group (12%) (P < 0.001).

conclusionsThe single loading dose of dexmedetomidine combined with propofol can reduce propofol consumption and artificial airway intervention and provide better hemodynamic stability than propofol for deep sedation in elderly patients during ERCP.

trial registrationwww.chictr.org.cn (Registration number ChiCTR1900028069, Registration date 10/12/2019).

Indexed as

Deep SedationDexmedetomidinePropofolAgedCholangiopancreatography, Endoscopic RetrogradeHumansHypnotics and SedativesProspective StudiesDexmedetomidineHypnotics and SedativesPropofolDeep sedationDexmedetomidineElderly patientsEndoscopic retrograde cholangiopancreatographyPropofol

Identifiers

PMID35346041
PMCPMC8961946
OpenAlexW4220864217

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.