Evidence map›Paper›PMID 35345873›Full record

ReviewContemporary clinical trials communications2022

Demystifying radiation oncology clinical trial concerns for protocol scientific review and institutional review board committee members.

Jamiluddin Qazi, Kristi A DeHaai, Benjamin M Hawkins, Kara D Romano, Nicholas G Zaorsky, Ronald C Chen, Timothy N Showalter

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Contemporary clinical trials communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Protocol-in-a-Day Workshop: Expediting IRB Approval for Junior and Senior Faculty.Journal of cancer education : the official journal of the American Association for Cancer Education · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Jamiluddin QaziDepartment of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Kristi A DeHaaiInstitutional Review Board for Health Sciences Research, University of Nebraska Medical Center, Omaha, NE, USA.
Benjamin M HawkinsUniversity of Virginia School of Law, Charlottesville, VA, USA.
Kara D RomanoDepartment of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Nicholas G ZaorskyDepartment of Radiation Oncology, Penn State Cancer Institute, Hershey, PA, USA.
Ronald C ChenDepartment of Radiation Oncology, University of Kanas School of Medicine, Kansas City, KA, USA.
Timothy N ShowalterDepartment of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, VA, USA.
University of Virginia · USKaw Nation · USNebraska Medical Center · USPennsylvania State University · US

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Jay William FOX · 1987 to 2026
$72.1M
NCI NIH HHS P30 CA044579
6 · The paper itself

Abstract

Clinical trials are essential for evaluating advanced technologies and treatment approaches involving radiation therapy to improve outcomes for cancer patients. Clinical trials at cancer centers with designation from the National Cancer Institute must undergo scientific review in additional to Institutional Review Board approval. Given the highly specialized nature and rapidly advancing technologies of radiation therapy, and the small number of radiation oncology investigators at some centers, a lack of radiation oncology expertise among reviewers may present challenges at some cancer centers. This commentary aims to provide an overview of radiation therapy and special considerations for radiation oncology research that will serve as a helpful resource in the scientific review of clinical trials involving cancer patients.

Indexed as

Clinical trialsInstitutional review boardProtocol reviewRadiation oncologyRadiation therapy

Identifiers

PMID35345873
PMCPMC8956792
OpenAlexW4220766142

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.