Evidence map›Paper›PMID 35345699›Full record

ReviewCureus2022

Neuropathic Pain in Neurologic Disorders: A Narrative Review.

Dimos-Dimitrios Mitsikostas, Eleni Moka, Enrique Orrillo, Caterina Aurilio, Athina Vadalouca, Antonella Paladini, Giustino Varrassi

Open access · diamondAbstract readReview
In one paragraph

Review in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Semaphorins and Their Role in Neuropathic Pain.Life (Basel, Switzerland) · 2026
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  8. Sonographic anatomy and imaging of the great auricular nerve.Surgical and radiologic anatomy : SRA · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Dimos-Dimitrios MitsikostasFirst Department of Neurology, Eginition Hospital, National and Kapodistrian University of Athens, Athens, GRC.
Eleni MokaDepartment of Anesthesiology, Creta Interclinic Hospital, Herakleion, GRC.
Enrique OrrilloPain Medicine, Asociacion Peruana para el Estudio del Dolor, Lima, PER.
Caterina AurilioDepartment of Anaesthesiology, University of Napoli, Napoli, ITA.
Athina VadaloucaPain and Palliative Care Center, Athens Medical Hospital, Athens, GRC.
Antonella PaladiniDepartment of Life, Health and Environmental Sciences (MESVA), University of L'Aquila, L'Aquila, ITA.
Giustino VarrassiPain Management, Paolo Procacci Foundation, Rome, ITA.
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli · ITUniversity of L'Aquila · ITAsociación para la Conservación de la Cuenca Amazónica · PEEginition Hospital · GRFondazione Roma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuropathic pain is defined as a painful condition caused by neurological lesions or diseases. Sometimes, neurological disorders may also be associated with neuropathic pain, which can be challenging to manage. For example, multiple sclerosis (MS) may cause chronic centralized painful symptoms due to nerve damage. Other chronic neuropathic pain syndromes may occur in the form of post-stroke pain, spinal cord injury pain, and other central pain syndromes. Chronic neuropathic pain is associated with dysfunction, disability, depression, disturbed sleep, and reduced quality of life. Early diagnosis may help improve outcomes, and pain control can be an important factor in restoring function. There are more than 100 different types of peripheral neuropathy and those involving sensory neurons can provoke painful symptoms. Accurate diagnosis of peripheral neuropathy is essential for pain control. Further examples are represented by gluten neuropathy, which is an extraintestinal manifestation of gluten sensitivity and presents as a form of peripheral neuropathy; in these unusual cases, neuropathy may be managed with diet. Neuropathic pain has been linked to CoronaVirus Disease (COVID) infection both during acute infection and as a post-viral syndrome known as long COVID. In this last case, neuropathic pain relates to the host's response to the virus. However, neuropathic pain may occur after any critical illness and has been observed as part of a syndrome following intensive care unit hospitalization.

Indexed as

long covidmultiple sclerosisneurological disordersneuropathic painpainpost-stroke pain

Identifiers

PMID35345699
PMCPMC8942164
OpenAlexW4213098465

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.