Evidence map›Paper›PMID 35345665›Full record

ArticleOpen forum infectious diseases2022

Candidemia Among Coronavirus Disease 2019 Patients in Turkey Admitted to Intensive Care Units: A Retrospective Multicenter Study.

Amir Arastehfar, Nevzat Ünal, Tuğrul Hoşbul, Muhammed Alper Özarslan, Ayşe Sultan Karakoyun, Furkan Polat, Diego Fuentes, Ramazan Gümral, Tuba Turunç, Farnaz Daneshnia and 5 more

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Profound cell wall remodeling inMicrobiology spectrum · 2026
    Article
  5. Article
  6. Clinical characteristics and risk factors of mortality in patients with candidemia: a four-year retrospective study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Increase in candidemia cases and emergence of fluconazole-resistantEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024
    Article
  12. Analysis of clinicalAntimicrobial agents and chemotherapy · 2024
    Article
  13. Article
  14. Article
  15. Analysis of clinicalbioRxiv : the preprint server for biology · 2023
    Article
  16. The Clinical Characteristics of Bloodstream Infections Due toJournal of fungi (Basel, Switzerland) · 2023
    Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 4 countries.

Amir ArastehfarCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Nevzat ÜnalUniversity of Health Sciences, Adana City Training and Research Hospital, Laboratory of Medical Microbiology, Adana, Turkey.
Tuğrul HoşbulDepartment of Microbiology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
Muhammed Alper ÖzarslanDepartment of Microbiology, Faculty of Medicine, Ege University, Izmir, Turkey.
Ayşe Sultan KarakoyunDivision of Mycology, Faculty of Medicine, Çukurova University, Adana, Turkey.
Furkan PolatDepartment of Microbiology, Faculty of Medicine, Ege University, Izmir, Turkey.
Diego FuentesLife Sciences Programme, Supercomputing Center (BSC-CNS), Barcelona, Spain.ORCID https://orcid.org/0000-0002-9977-6786
Ramazan GümralDepartment of Microbiology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey.
Tuba TurunçUniversity of Health Sciences, Adana Faculty of Medicine, Adana City Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Adana, Turkey.
Farnaz DaneshniaCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
David S PerlinCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Cornelia Lass-FlörlDivision of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Toni GabaldónLife Sciences Programme, Supercomputing Center (BSC-CNS), Barcelona, Spain.
Macit IlkitDivision of Mycology, Faculty of Medicine, Çukurova University, Adana, Turkey.ORCID https://orcid.org/0000-0002-1174-4182
M Hong NguyenDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Sağlık Bilimleri Üniversitesi · TRHackensack Meridian Health · USCukurova University · TREge University · TRBarcelona Supercomputing Center · ESInnsbruck Medical University · ATInstitució Catalana de Recerca i Estudis Avançats · ESUniversity of Pittsburgh · US

Funding

Genomic diversity of Candida bloodstream infectionsR21AI160098 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NGUYEN, M. HONG THI · 2021 to 2022
$499k
Polyclonality of carbapenem resistant Enterobacteriaceae bloodstream infectionsR21AI152018 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CLANCY, CORNELIUS J · 2021 to 2022
$462k
NIAID NIH HHS R21 AI152018NIAID NIH HHS R21 AI160098
6 · The paper itself

Abstract

Background: We evaluated the epidemiology of candidemia among coronavirus disease 2019 (COVID-19) patients admitted to intensive care units (ICUs). Methods: We conducted a retrospective multicenter study in Turkey between April and December 2020. Results: Twenty-eight of 148 enrolled patients developed candidemia, yielding an incidence of 19% and incidence rate of 14/1000 patient-days. The probability of acquiring candidemia at 10, 20, and 30 days of ICU admission was 6%, 26%, and 50%, respectively. More than 80% of patients received antibiotics, corticosteroid, and mechanical ventilation. Receipt of a carbapenem (odds ratio [OR] = 6.0, 95% confidence interval [CI] = 1.6-22.3, Conclusions: Physicians should be aware of the elevated risk for candidemia among patients with COVID-19 who require ICU care. Prolonged ICU exposure and ICU practices rendered to COVID-19 patients are important contributing factors to candidemia. Emphasis should be placed on (1) heightened infection control in the ICU and (2) developing antibiotic stewardship strategies to reduce irrational antimicrobial therapy.

Indexed as

bacteremiacandidemiaCOVID-19fluconazole resistanceinfection control

Identifiers

PMID35345665
PMCPMC8903397
OpenAlexW4212984927

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.