ReviewFrontiers in pediatrics2022
Diagnosis of Neonatal Sepsis: The Role of Inflammatory Markers.
Review in Frontiers in pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
101 citing papers in PubMed, 2 syntheses or guidelines pooled it, 154 citations in OpenAlex.
- Diagnostic accuracy of interleukin-6 (IL-6) as a significant biomarker in late-onset neonatal sepsis: an updated systematic review and meta-analysis.European journal of pediatrics · 2025Pooled it
- Systematic review and meta-analysis of the diagnostic value of four biomarkers in detecting neonatal sepsis in low- and middle-income countries.BMJ paediatrics open · 2023Pooled it
- Essential Fatty Acid Supplementation and Early Inflammation in Preterm Infants: Secondary Analysis of a Randomized Clinical Trial.Neonatology · 2023Trial
- The Goldilocks zone of optimal antimicrobial stewardship in preterm infants.Pediatric research · 2026Article
- Comparative Diagnostic Performance of RDW-to-Albumin and CRP-to-Albumin Ratios in Neonatal Sepsis: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- Cord blood procalcitonin and soluble urokinase-type plasminogen activator receptor in predicting histological chorioamnionitis - A pilot study.European journal of obstetrics & gynecology and reproductive biology: X · 2026Article
- Neonatal Bloodstream Infections: A Narrative Review on Diagnostic and Therapeutic Challenges and Prospects in Developing Countries.Health science reports · 2026Article
- Factors Associated with Antibiotic Initiation After DaBT-Hib-IPV Vaccination in NICU-Hospitalized Preterm Infants: The Role of C-Reactive Protein.Journal of clinical medicine · 2026Article
- Diagnostic utility of neutrophil CD64 for early detection of neonatal sepsis in southwestern Nigeria: a comparative case-control study.BMC pediatrics · 2026Article
- Evaluation of sequential serum amyloid A measurements for the prediction of sepsis and survival in critically ill neonatal foals.Journal of veterinary internal medicine · 2026Article
- Birth and neonatal risk factors associated with neonatal conjunctivitis: a retrospective case-control study.BMC pediatrics · 2026Article
- Multi-omics insights into immunometabolic dysregulation in neonatal sepsis for precision medicine.Molecular biology reports · 2026Review
- Is the Neonatal Sepsis Screen More Futile Than Useful in Clinical Practice? Yes.Indian pediatrics · 2026Article
- Prevalence, Maternal Risk Factors, and Neonatal Outcomes of Early-Onset Neonatal Septicemia: A Retrospective Study.Cureus · 2026Article
- On the usage of artificial intelligence for identifying main attributes and predicting neonatal sepsis.Scientific reports · 2026Article
- Article
- Diagnostic utility of serum ferritin in culture proven bacterial infection: an observational study.BMC infectious diseases · 2026Observational
- Early postoperative inflammatory markers associated with anastomotic leakage after repair of congenital esophageal atresia.BMC pediatrics · 2026Article
- Neonatal Hydrops and Biliary Atresia as an Early Presentation of Mevalonate Kinase Deficiency: A Case Report.Cureus · 2026Article
- Evaluation of the Course of Acute-Phase Reactants in the Postoperative Period of Newborns and Their Diagnostic Utility in Identifying Postoperative Sepsis.Diagnostics (Basel, Switzerland) · 2026Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This is a narrative review on the role of biomarkers in the diagnosis of neonatal sepsis. We describe the difficulties to obtain standardized definitions in neonatal sepsis and discuss the limitations of published evidence of cut-off values and their sensitivities and specificities. Maternal risk factors influence the results of inflammatory markers as do gestational age, the time of sampling, the use of either cord blood or neonatal peripheral blood, and some non-infectious causes. Current evidence suggests that the use of promising diagnostic markers such as CD11b, CD64, IL-6, IL-8, PCT, and CRP, either alone or in combination, might enable clinicians discontinuing antibiotics confidently within 24-48 h. However, none of the current diagnostic markers is sensitive and specific enough to support the decision of withholding antibiotic treatment without considering clinical findings. It therefore seems to be justified that antibiotics are often initiated in ill term and especially preterm infants. Early markers like IL-6 and later markers like CRP are helpful in the diagnosis of neonatal sepsis considering the clinical aspect of the neonate, the gestational age, maternal risk factors and the time (age of the neonate regarding early-onset sepsis) of blood sampling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.