Evidence map›Paper›PMID 35345546›Full record

ArticleFrontiers in neuroscience2022

PET Imaging of Synaptic Density: Challenges and Opportunities of Synaptic Vesicle Glycoprotein 2A PET in Small Animal Imaging.

Takuya Toyonaga, Arman Fesharaki-Zadeh, Stephen M Strittmatter, Richard E Carson, Zhengxin Cai

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. The role of nuclear medicine in neurodegenerative diseases: a narrative review.American journal of neurodegenerative disease · 2025
    Review
  6. Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Takuya ToyonagaPositron Emission Tomography (PET) Center, Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States.
Arman Fesharaki-ZadehPsychiatry, Yale School of Medicine, New Haven, CT, United States.
Stephen M StrittmatterNeurology, Yale School of Medicine, New Haven, CT, United States.
Richard E CarsonPositron Emission Tomography (PET) Center, Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States.
Zhengxin CaiPositron Emission Tomography (PET) Center, Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, United States.
Itron (United States) · USYale University · US

Funding

Yale Alzheimer Disease Research CenterP30AG066508 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER, CHRISTOPHER H VAN DYCK · 2020 to 2026
$30.2M
Prion Protein in Alzheimer's Disease PathophysiologyR01AG034924 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER · 2010 to 2026
$9.6M
Silent Allosteric Modulation of mGluR5 for Safe and Effective Therapy of Alzheimer's DiseaseU01AG058608 · NIA · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2018 to 2022
$8.5M
Sex-Specific Single Cell Expression Profiles, Genetic Risk and Drug Responsiveness in Alzheimer's DiseaseR56AG074015 · NIA · YALE UNIVERSITY · PI GHOSH, SOURAV, ROTHLIN, CARLA · 2021 to 2022
$2.5M
Synaptic selectivity for microglial-mediated damage in Alzheimer's DiseaseRF1AG070926 · NIA · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2021 to 2021
$2.4M
NIA NIH HHS P30 AG066508NIA NIH HHS R01 AG034924NIA NIH HHS RF1 AG070926NIA NIH HHS U01 AG058608
6 · The paper itself

Abstract

The development of novel PET imaging agents for synaptic vesicle glycoprotein 2A (SV2A) allowed for the

Indexed as

brain PETneurodegenerationsmall animalSV2Asynapse

Identifiers

PMID35345546
PMCPMC8957200
OpenAlexW4220991753

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.