Reprogramming bone progenitor identity and potency through control of collagen density and oxygen tension.

Rawiya Al Hosni, Laurent Bozec, Scott J Roberts, Umber Cheema

Abstract read

In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

Patient-specific colorectal-cancer-associated fibroblasts modulate tumor microenvironment mechanics.iScience · 2024
Article
The potential role of mechanotransduction in the management of pediatric calvarial bone flap repair.Biotechnology and bioengineering · 2024
Review
Evaluating the Impact of a Biomimetic Mechanical Environment on Cancer Invasion and Matrix Remodeling.Advanced healthcare materials · 2023
Article
RANKL neutralisation prevents osteoclast activation in a humanJournal of tissue engineering
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rawiya Al HosniUCL Centre for 3D Models of Health and Disease, Division of Surgery and Interventional Sciences, University College London, 43-45 Foley St, Fitzrovia, W1W 7TY London, UK.

Laurent BozecFaculty of Dentistry, University of Toronto, 12 Edward Street, Toronto, ON M5G 1G6, Canada.

Scott J RobertsUCL Centre for 3D Models of Health and Disease, Division of Surgery and Interventional Sciences, University College London, 43-45 Foley St, Fitzrovia, W1W 7TY London, UK.

Umber CheemaUCL Centre for 3D Models of Health and Disease, Division of Surgery and Interventional Sciences, University College London, 43-45 Foley St, Fitzrovia, W1W 7TY London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The biophysical microenvironment of the cell is being increasingly used to control cell signaling and to direct cell function. Herein, engineered 3D tuneable biomimetic scaffolds are used to control the cell microenvironment of Adipose-derived Mesenchymal Stromal Cells (AMSC), which exhibit a collagen density-specific profile for early and late stage bone cell lineage status. Cell potency was enhanced when AMSCs were cultured within low collagen density environments in hypoxic conditions. A transitional culture containing varied collagen densities in hypoxic conditions directed differential cell fate responses. The early skeletal progenitor identity (PDPN

Indexed as

BiophysicsCell biologyDevelopmental biologyStem cells research

Identifiers

PMID35345460

DOI10.1016/j.isci.2022.104059

PMCPMC8957015

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.