ArticleFrontiers in surgery2022
Value of CRP, PCT, and NLR in Prediction of Severity and Prognosis of Patients With Bloodstream Infections and Sepsis.
Article in Frontiers in surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
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Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Association between neutrophil to lymphocyte ratio and the mortality of patients with sepsis: an update systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Predictive value of the neutrophil-to-lymphocyte ratio in the prognosis and risk of death for adult sepsis patients: a meta-analysis.Frontiers in immunology · 2024Pooled it
- Determinants of mortality in carbapenem-resistant Klebsiella pneumoniae ICU Infections: a multivariable clinical and predictive modeling analysis.BMC infectious diseases · 2026Article
- The predictive value of the ratio of multi-dimensional inflammatory biomarkers in pediatric diseases from the perspective of pro-inflammatory/anti-inflammatory balance: a systematic review.Translational pediatrics · 2026Review
- Neutrophil-Lymphocyte-Platelet Ratio for Predicting Bacteremia in Immunosuppressed Cancer Patients: A Retrospective Diagnostic Accuracy Study.Biomedicines · 2026Article
- Article
- Integrating serum ferritin and neutrophil-to-lymphocyte ratio with Sequential Organ Failure Assessment score improves mortality prediction in sepsis.World journal of methodology · 2026Article
- Endoscopic stenting as salvage therapy for high-risk Boerhaave's syndrome patients.Journal of thoracic disease · 2026Article
- A machine learning model for the early prediction of Gram-negative bloodstream infection in ICU patients.BMC medical informatics and decision making · 2026Article
- Prognostic Value of the Advanced Lung Cancer Inflammation Index for Predicting in-Hospital Mortality in Intensive Care Unit Patients with Septic Shock: A Retrospective Cohort Study.Journal of inflammation research · 2026Article
- Diagnostic utility of procalcitonin in determining Gram-negative and Gram-positive bacterial bloodstream infections: a single-centre study from South India.Frontiers in medicine · 2026Article
- Combined prognostic value of the neutrophil-to-lymphocyte ratio and serum lactate for 28-day mortality in patients with sepsis-induced pulmonary dysfunction.American journal of translational research · 2026Article
- Development and optimization of host DNA depletion in blood cultures using a saponin and salt-activated nuclease-based method.Frontiers in microbiology · 2026Article
- Severity and 28-day in-hospital mortality of interleukin-6, neutrophil to lymphocyte ratio, and APACHE II score in patients with sepsis.Frontiers in cellular and infection microbiology · 2026Article
- The Value of First-Day CRP and NLR in Distinguishing Infectious from Non-Infectious Causes of Loss of Consciousness in the Emergency Department.Open access emergency medicine : OAEM · 2026Article
- The Association Between C-Reactive Protein-to-Albumin Ratio and in-Hospital Mortality in Patients withJournal of inflammation research · 2026Article
- Identification of Prognostic Factors for Sepsis or Septic Shock Patients with Cardiac Dysfunction.Journal of cardiovascular translational research · 2025Article
- Evaluation of Testican-1 as a Sepsis Biomarker in Pyometra Cats.Veterinary medicine and science · 2025Article
- Association between the nutritional inflammation index and mortality among patients with sepsis: insights from traditional methods and machine learning-based mortality prediction.BMC infectious diseases · 2025Article
- Procalcitonin and interleukin- 6 in predicting prognosis of sepsis patients with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate the value of C-reactive protein (CRP), procalcitonin (PCT), and neutrophil to lymphocyte ratio (NLR) in assessing the severity of disease in patients with bloodstream infection and sepsis, and to analyze the relationship between the levels of three inflammatory factors and the prognosis of patients. Methods: The clinical data of 146 patients with bloodstream infection and sepsis admitted to our intensive care unit (ICU) from October 2016 to May 2020 were retrospectively analyzed. The differences in the levels of inflammatory indicators such as CRP, PCT, and NLR within 24 h in patients with bloodstream infection sepsis with different conditions (critical group, non-critical group) and the correlation between these factors and the condition (acute physiology and chronic health evaluation II, APACHE II score) were analyzed. In addition, the prognosis of all patients within 28 days was counted, and the patients were divided into death and survival groups according to their mortality, and the risk factors affecting their death were analyzed by logistic regression, and the receiver operating characteristic (ROC) curve was used to analyze the value of the relevant indicators in assessing the prognosis of patients. Results: The levels of NLR, CRP, PCT, total bilirubin (TBIL), glutamic oxaloacetic transaminase (AST), and serum creatinine (Scr) were significantly higher in the critically ill group than in the non-critically ill group, where correlation analysis revealed a positive correlation between CRP, PCT, and NLR and APACHE II scores ( Conclusion: Inflammatory factors such as NLR, CRP, and PCT have important clinical applications in the assessment of the extent of disease and prognosis of patients with bloodstream infection and sepsis.
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