Evidence map›Paper›PMID 35345377›Full record

SynthesisAsian Pacific journal of cancer prevention : APJCP2022

Comparison of Salivary Electrolytes Profile in Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma.

Juan Aitken Saavedra, Diogo La Rosa Novo, Marcia Foster Mesko, Ana Carolina Uchoa Vasconcellos, Karine Duarte Da Silva, Gabriel Rojas Zuñiga, Ricardo Fernandes Ramires, Sandra Beatriz Chaves Tarquinio

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Asian Pacific journal of cancer prevention : APJCP, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Juan Aitken SaavedraDepartment of Oral Pathology and Medicine, Faculty of Dentistry, University of Chile, Santiago, Chile.ORCID 0000-0002-2525-8433
Diogo La Rosa NovoCenter of Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas. Capão do Leão, RS, Brazil.ORCID 0000-0002-3668-3494
Marcia Foster MeskoCenter of Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas. Capão do Leão, RS, Brazil.
Ana Carolina Uchoa VasconcellosDiagnostic Center for Oral Diseases, Federal University of Pelotas. Pelotas, RS, Brazil.
Karine Duarte Da SilvaCentro Universitário Ritter dos Reis, UniRitter, Porto Alegre, Rio Grande do Sul, Brazil.
Gabriel Rojas ZuñigaDepartment of Oral Pathology and Medicine, Faculty of Dentistry, University of Chile, Santiago, Chile.
Ricardo Fernandes RamiresCentro de Oncologia de Precisión-Universidad Mayo, Brazil.
Sandra Beatriz Chaves TarquinioDiagnostic Center for Oral Diseases, Federal University of Pelotas. Pelotas, RS, Brazil.ORCID 0000-0003-1496-4137
Universidade Federal de Pelotas · BRUniversity of Chile · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesto determine salivary electrolyte concentration of oral potentially malignant disorders (OPMD) and oral squamous cell carcinoma (OSCC) patients. A related systematic review was performed.

methodsObservational study. Unstimulated saliva from 18 patients with OSCC, 18 with OPMD, and 18 without oral lesions was collected. A biochemical analysis was performed to evaluate the salivary concentrations of potassium (K), phosphorus (P), sodium (Na), calcium (Ca), magnesium (Mg), zinc (Zn), copper (Cu), and iron (Fe). Kruskal-Wallis test was performed, and p < 0.05 was interpreted as statistically significant. The literature search for the systematic review retrieved 9 studies that associated salivary electrolyte levels with presence and progression of OSCC.

resultsA highly significant increase was found in the salivary Mg levels in the OPMD group (5.41 µg/mL) in comparison with the OSCC (3.71µg/mL) and control group (3.51 µg/mL) (p = 0.041). No differences were observed in other salivary levels elements. The results of the systematic review revealed that one article indicated a decrease, and three papers reported an increase in salivary Na levels in patients with OPMD and OSCC. Two articles indicated a decrease in salivary K levels in OSCC, and the other two reported high Mg levels in OPMD and OSCC.

conclusionHigh salivary Mg levels can be a potential biomarker indicating the presence of OPMD, however, the evidence is still contradictory and more studies are required.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsMouth NeoplasmsElectrolytesHumansObservational Studies as TopicSquamous Cell Carcinoma of Head and NeckElectrolytesElectrolytesPrecancerous ConditionSalivatrace elements

Identifiers

PMID35345377
PMCPMC9360961
OpenAlexW4220858979

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.