Evidence map›Paper›PMID 35345355›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2022

Epithelial-Mesenchymal Transition Markers in HCVAssociated Hepatocellular Carcinoma: A Multivariate Follow Up Study.

Thanaa Elsayed Helal, Ahmed Aref, Asmaa Ibrahim Gomaa, Ola Nada, Mohamed Abd-Elghaffar, Khaled Farouk, Nermine Ahmed Ehsan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  6. Polyhydroxylated Fullerene CJournal of inflammation research · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Thanaa Elsayed HelalDepartment of Pathology, Faculty of Medicine, Ain Shams University, Cairo Egypt.
Ahmed ArefOctober University for Modern Science and Arts, Giza, Egypt.
Asmaa Ibrahim GomaaDepartment of Pathology, National Liver Institute, Menoufia University, Egypt.
Ola NadaDepartment of Pathology, Faculty of Medicine, Ain Shams University, Cairo Egypt.
Mohamed Abd-ElghaffarDepartment of Surgery, Faculty of Medicine, Ain Shams University, Cairo Egypt.
Khaled FaroukDepartment of Pathology, Faculty of Medicine, Six October University, Cairo, Egypt.
Nermine Ahmed EhsanDepartment of Pathology, National Liver Institute, Menoufia University, Egypt.ORCID 0000-0003-4493-6647
Ain Shams University · EGMenoufia University · EGOctober University of Modern Sciences and Arts · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveValidated markers to predict recurrence after surgical resection of hepatocellular carcinoma (HCC) are needed. Little data is available regarding epithelial-mesenchymal transition (EMT) markers in HCC. The objective of this study was to investigate the expression of EMT markers and their correlation with clinicopathological variables and survival in hepatitis C virus (HCV)-associated HCC.

methodsThis longitudinal study included 109 cases of HCV-associated HCC treated with surgical resection. Nine different EMT markers (vimentin, E-cadherin, N-cadherin, Stat3, Snail1, Slug, Twist1, Zeb1 and integrin α5) were evaluated on liver tissue from HCC cases. Twenty fresh HCC samples from the studied cases were used for gene expression of EMT markers by quantitative real time polymerase chain reaction (PCR).

resultsEMT markers expression was 71%, 25%, 26%, 27%, 9%, 4%, 72%, 47%, 87% for vimentin, E-cadherin, N-cadherin, Stat3 snail1, slug, twist1, Zeb1 and integrin α5 respectively.  EMT mRNA in HCC tissues correlated with protein expression by 50-70%.  Vimentin was independent predictor of large tumor size (P=0.001), high risk of recurrence (HRR) (P=0.006) and shorter disease free survival (P=0.03) in multivariate analysis.  Reduced E-cadherin was a predictor of HRR (P=0.002).

conclusionVimentin and E-cadherin were the most powerful prognostic EMT markers in HCV-associated HCC in prediction of recurrence.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsEpithelial-Mesenchymal TransitionFollow-Up StudiesHumansLongitudinal StudiesEpithelial-mesenchymal transition markersHCVHepatocellular carcinomaPrognosis

Identifiers

PMID35345355
PMCPMC9360938
OpenAlexW4220714448

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.