ArticleNature2022
A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic.
Abstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers.
0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
135 citing papers in PubMed.
- TMPRSS2 inhibitors with broad-spectrum efficacy against SARS-CoV-2 (JN.1) and influenza A (H1N1) viruses protect mice from influenza A infection.Emerging microbes & infections · 2026Article
- Discovery of Highly Selective Noncovalent Macrocyclic Peptide Inhibitors Suppressing Both TMPRSS2 Protease Activity and Viral Receptor Function.Journal of medicinal chemistry · 2026Article
- Recent Advances in the Design of Inhibitors Targeting the Viral Entry and Replication of the SARS-CoV-2 Virus, Driven by In Silico Approaches.Molecules (Basel, Switzerland) · 2026Review
- Hepatocyte growth factor activator inhibitor-2 rapidly inactivates airway-expressed human type II transmembrane serine proteases.The Journal of biological chemistry · 2026Article
- Repurposing screens reveal a role for PKCη and NF1 in SARS-CoV-2 infection.PLoS pathogens · 2026Article
- DNA oligonucleotides block viral entry of SARS-CoV-2 Omicron variants.PLoS pathogens · 2026Article
- Lock out: targeting TMPRSS2 to block influenza and coronaviruses.Journal of virology · 2026Review
- Targeting SARS-CoV-2 Structural and Accessory Proteins: Emerging Opportunities for Small-Molecule Coronavirus Antivirals.Pharmaceutics · 2026Review
- A reversible broad-spectrum antiviral targets the human V-ATPase VResearch square · 2026Article
- Extending the Targets for Coronavirus Antivirals Beyond That of Approved Drugs: Insights From Preclinical Research.Microbial biotechnology · 2026Review
- TMPRSS2-mediated coronavirus spike activation and inhibition.Nature structural & molecular biology · 2026Article
- 3-Amidinophenylalanine-Derived Inhibitors' Antiviral Effect Against H1N1 Influenza A Virus.Antibiotics (Basel, Switzerland) · 2026Article
- Structural Basis of Serine Protease Inhibition by Antibodies from Biased Fab Phage-Display Libraries.bioRxiv : the preprint server for biology · 2026Article
- FGFR signaling and neddylation facilitate SARS-CoV-2 infection by modulating interferon induction and viral entry, respectively.iScience · 2026Article
- Searching for Novel Antiviral Agents as COVID19 Treatments: Guanidino Diaryl Thioureas.ChemMedChem · 2026Article
- PoMA-10: a dual-action antiviral disrupting SARS-CoV-2 Spike-ACE2 interaction and protecting lung tissue.Frontiers in pharmacology · 2026Article
- Development of ketobenzothiazole-based peptidomimetic TMPRSS13 inhibitors with low nanomolar potency.Journal of enzyme inhibition and medicinal chemistry · 2025Article
- Pharmacoinformatics-based screening and construction of a neutralizing anti-SARS-CoV-2 camelidae nanobody drug conjugate.Molecular diversity · 2025Article
- LL-37 Inhibits TMPRSS2-Mediated S2' Site Cleavage and SARS-CoV-2 Infection but Not Omicron Variants.Cell proliferation · 2025Article
- MERS-CoV and SARS-CoV-2 infection in diverse human lung organoid-derived cultures.Journal of virology · 2025Article
75 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
26 authors.
Tirosh Shapira *Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
I Abrrey Monreal *Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.ORCID http://orcid.org/0000-0003-0521-9063
Sébastien P DionDepartment of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada.ORCID http://orcid.org/0000-0002-8961-0782
David W BuchholzDepartment of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.ORCID http://orcid.org/0000-0001-8874-6648
Brian ImbiakhaDepartment of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.
Andrea D OlmsteadDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0002-1110-1291
Mason JagerDepartment of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.ORCID http://orcid.org/0000-0001-6036-9895
Antoine DésiletsDepartment of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada.ORCID http://orcid.org/0000-0001-5081-5564
Guang GaoDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Mathias MartinsDepartment of Population Medicine and Diagnostic Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.ORCID http://orcid.org/0000-0002-8290-5756
Thierry VandalDepartment of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Connor A H ThompsonDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Aaleigha ChinDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
William D ReesDepartment of Medicine, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0002-3171-3068
Theodore SteinerDepartment of Medicine, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
Ivan Robert NabiDepartment of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0002-0670-0513
Eric MarsaultDepartment of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Julie SahlerDepartment of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.
Diego G DielDepartment of Population Medicine and Diagnostic Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.
Gerlinde R Van de WalleDepartment of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.ORCID http://orcid.org/0000-0002-2064-8029
Avery AugustDepartment of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.ORCID http://orcid.org/0000-0003-4968-3415
Gary R WhittakerDepartment of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.
Pierre-Luc BoudreaultDepartment of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada.ORCID http://orcid.org/0000-0002-2032-7970
Richard LeducDepartment of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada. richard.leduc@usherbrooke.ca.ORCID http://orcid.org/0000-0001-6854-8003
Hector C AguilarDepartment of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA. ha363@cornell.edu.ORCID http://orcid.org/0000-0001-6879-8360
François JeanDepartment of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada. fjean@mail.ubc.ca.ORCID http://orcid.org/0000-0002-6148-7460
Funding
Mechanisms of Nipah virus fusion and entryR01AI109022 · NIAID · WASHINGTON STATE UNIVERSITY · PI AGUILAR-CARRENO, HECTOR · 2014 to 2024
$4.3MCornell Initiative for Maximizing Student DevelopmentR25GM125597 · NIGMS · CORNELL UNIVERSITY · PI AUGUST, AVERY · 2018 to 2022
$2.2MRegulation of IL10 production in CD8+ T cells during Flu infection by tyrosine kinase ItkR01AI138570 · NIAID · CORNELL UNIVERSITY · PI AUGUST, AVERY · 2018 to 2022
$2.1MImmuno-Engineering: Integrated Engineering and Immunology TrainingT32EB023860 · NIBIB · CORNELL UNIVERSITY · PI AUGUST, AVERY, PUTNAM, DAVID A · 2018 to 2022
$933kNIAID NIH HHS R01 AI109022NIAID NIH HHS R01 AI138570NIBIB NIH HHS T32 EB023860NIGMS NIH HHS R25 GM125597
Abstract
The COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced owing to emerging variants of concern
Indexed as
COVID-19SARS-CoV-2Serine Proteinase InhibitorsAnimalsDisease Models, AnimalHumansMiceMice, TransgenicSerine EndopeptidasesSpike Glycoprotein, CoronavirusVirus InternalizationSerine EndopeptidasesSerine Proteinase InhibitorsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2TMPRSS2 protein, human
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.