ArticleCells, tissues, organs2023
Static Magnetic Field Promotes Proliferation, Migration, Differentiation, and AKT Activation of Periodontal Ligament Stem Cells.
Article in Cells, tissues, organs, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Arrayed Magnetic Accelerator Synergistically Enhances Orthodontic Tooth Movement via Microtubule Assembly-Mediated Periodontal Remodeling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Immunoengineering External Field Responsive Biomaterials for Tissue Repair and Regeneration.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Controllable Dynamic Mechanical Cell Stimulation using Magnetically Actuated Artificial Cilia.Advanced healthcare materials · 2026Article
- Functionalized chitosan-graphene magnetic nanocomposites enhance collagen synthesis in scleral fibroblasts.Open life sciences · 2026Article
- miR-508-5p suppresses osteogenic differentiation of human periodontal ligament stem cells via targeting sex-determining region Y-related HMG-box 11.Journal of dental sciences · 2025Article
- Moderate static magnetic field regulates iron metabolism and salvage bone loss caused by iron accumulation.Journal of orthopaedic translation · 2025Article
- Cellular and Molecular Effects of Magnetic Fields.International journal of molecular sciences · 2024Review
- Static magnetic field-modulated mesenchymal stem cell-derived mitochondria-containing microvesicles for enhanced intervertebral disc degeneration therapy.Journal of nanobiotechnology · 2024Article
- Static magnetic field-induced IL-6 secretion in periodontal ligament stem cells accelerates orthodontic tooth movement.Scientific reports · 2024Article
- Static magnetic fields in regenerative medicine.APL bioengineering · 2024Review
- Coupling of static ultramicromagnetic field with elastic micropillar-structured substrate for cell response.Materials today. Bio · 2023Article
- Moderate static magnetic field promotes fracture healing and regulates iron metabolism in mice.Biomedical engineering online · 2023Article
- Electrokinetic properties of healthy and β-thalassemia erythrocyte membranes underFrontiers in chemistry · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontal ligament stem cells (PDLSCs) possess self-renewal and multilineage differentiation potential and exhibit great potential for the treatment of bone tissue defects caused by inflammation. Previous studies have indicated that static magnetic field (SMF) can enhance the proliferation and differentiation of mesenchymal stem cells (MSCs). SMF has been widely used to repair bone defects and for orthodontic and implantation treatment. In this study, we revealed that a 320 mT SMF upregulates the protein expression levels of cytokines such as MCM7 and PCNA in proliferating PDLSCs. Cell counting kit-8 results revealed that the SMF group had higher optical density values than the control group. The ratio of cells in the S phase to those in the G2/M phase was significantly increased after exposure to a 320 mT SMF. In scratch assays, the SMF-treated PDLSCs exhibited a higher migration rate than the sham-exposed group after 24 h of culture, indicating that the SMF promoted the migratory ability of PDLSCs. The activity level of the early differentiation marker alkaline phosphatase and the late marker matrix mineralization, as well as osteoblast-specific gene and protein expression, were enhanced in PDLSCs exposed to the SMF. Furthermore, AKT signaling pathway was activated by SMF. Our data demonstrated that the potential mechanism of action of SMF may enhance PDLSCs proliferation and osteogenic differentiation by activating the phosphorylated AKT pathway. The elucidation of this molecular mechanism may lead to a better understanding of bone repair responses and aid in improved stem cell-mediated regeneration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.