ArticleNeurobiology of aging2022
The association between inadequate sleep and accelerated brain ageing.
Article in Neurobiology of aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Are sleep disturbances modifiable risk factors for mild cognitive impairment and dementia? A systematic review of large studies.Sleep & breathing = Schlaf & Atmung · 2025Pooled it
- Poor sleep is robustly correlated with accelerated aging but the evidence for causation is mixed.medRxiv : the preprint server for health sciences · 2026Article
- Distinct roles of chronotype, daytime napping, and sleep duration in biological and functional aging: a univariable and multivariable Mendelian randomization study.Clinical epigenetics · 2026Article
- Chronic sleep restriction activates complement and coagulation cascades: a molecular link to accelerated brain aging.Npj biological timing and sleep · 2026Article
- Brain age gap as a diffusion MRI-based marker of traumatic brain injury-related brain changes and associated outcomes.Brain communications · 2026Article
- Brain Age Acceleration on MRI Due to Poor Sleep: Associations, Mechanisms, and Clinical Implications.Brain sciences · 2025Review
- Chronic sleep curtailment expediates brain aging by activating the complement and coagulation cascades in mice.bioRxiv : the preprint server for biology · 2025Article
- Sleep quality, mental health, and cognitive function among older adults in Chinese communities: a cross-sectional study.Frontiers in public health · 2025Article
- More than chronic pain: behavioural and psychosocial protective factors predict lower brain age in adults with/at risk of knee osteoarthritis over two years.Brain communications · 2025Article
- Association of Self-Reported Sleep Characteristics With Neuroimaging Markers of Brain Aging Years Later in Middle-Aged Adults.Neurology · 2024Article
- Mechanisms, consequences and role of interventions for sleep deprivation: Focus on mild cognitive impairment and Alzheimer's disease in elderly.Ageing research reviews · 2024Review
- Meditation Experience is Associated with Increased Structural Integrity of the Pineal Gland and greater total Grey Matter maintenance.medRxiv : the preprint server for health sciences · 2024Article
- Comprehensive assessment of sleep duration, insomnia, and brain structure within the UK Biobank cohort.Sleep · 2024Article
- Adolescent brain maturation associated with environmental factors: a multivariate analysis.Frontiers in neuroimaging · 2024Article
- Sex-difference in the association between social drinking, structural brain aging and cognitive function in older individuals free of cognitive impairment.Frontiers in psychiatry · 2024Article
- Investigating the impact of motion in the scanner on brain age predictions.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Associations between polygenic risk scores and accelerated brain ageing in smokers.Psychological medicine · 2023Article
- Sleep quality and sleep duration predict brain microstructure among community-dwelling older adults.Neurobiology of aging · 2023Article
- A systematic review of multimodal brain age studies: Uncovering a divergence between model accuracy and utility.Patterns (New York, N.Y.) · 2023Review
- Total Sleep Deprivation Increases Brain Age Prediction Reversibly in Multisite Samples of Young Healthy Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Numerous studies indicate large heterogeneity in brain ageing, which can be attributed to modifiable lifestyle factors, including sleep. Inadequate sleep has been previously linked to gray (GM) and white (WM) matter changes. However, the reported findings are highly inconsistent. By contrast to previous research independently characterizing patterns of either GM or WM changes, we used here linked independent component analysis (FLICA) to examine covariation in GM, and WM in a group of older adults (n = 50). Next, we employed a novel technique to estimate the brain age delta (difference between chronological and brain age assessed using neuroimaging data) and study its associations with sleep quality and sleep fragmentation, hypothesizing that inadequate sleep accelerates brain ageing. FLICA revealed a number of multimodal components, associated with age, sleep quality, and sleep fragmentation. Subsequently, we show significant associations between brain age delta and inadequate sleep, suggesting 2 years deviation above the chronological age. Our findings indicate sensitivity of multimodal approaches and brain age delta in detecting link between inadequate sleep and accelerated brain ageing.
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Registered trials
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