ArticleMagnetic resonance in medicine2022
Inhomogeneous magnetization transfer MRI of white matter structures in the hypomyelinated shiverer mouse brain.
Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 5 citations in OpenAlex.
- Multiparametric MRI Can Detect Enhanced Myelination in the Ex Vivo Gli1NMR in biomedicine · 2025Article
- Remyelination in the Central Nervous System.Cold Spring Harbor perspectives in biology · 2024Review
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3 authors at 2 institutions in 1 country.
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Abstract
purposeInhomogeneous magnetization transfer (ihMT) MRI is uniquely sensitive to myelin with lipids as a primary source of its contrast. In this study, we investigated whether ihMT can detect white matter structures in the hypomyelinated shiverer mouse brain, a model of dysmyelination.
methodsConventional MT and ihMT images were acquired from ex vivo Rag2
resultsihMT ratio (ihMTR) maps revealed hypomyelinated corpus callosum in the shiverer mouse brain, whereas conventional MT ratio (MTR) maps showed no clear contrast. The ihMTR values of the corpus callosum in the shiverer mice were reduced by approximately 40% compared to controls, but remained significantly higher than the ihMTR values of the cortex.
conclusionThe finding further confirms ihMT's high myelin specificity and suggests its use as a marker to detect early myelination or myelin repair.
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