Evidence map›Paper›PMID 35344608›Full record

ArticleMagnetic resonance in medicine2022

SLOW: A novel spectral editing method for whole-brain MRSI at ultra high magnetic field.

Guodong Weng, Piotr Radojewski, Sulaiman Sheriff, Claus Kiefer, Philippe Schucht, Roland Wiest, Andrew A Maudsley, Johannes Slotboom

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06705010 (Non-Invasive Monitoring of Brain Metabolites Using Novel and Adapted Proton and Deuterium MR Techniques), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06705010 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Non-Invasive Monitoring of Brain Metabolites Using Novel and Adapted Proton and Deuterium MR Techniques

TypeinterventionalSponsorInsel Gruppe AG, University Hospital BernRan2025 to 2028Enrolled140ConditionsAging, Brain Metabolic Disorder, Carotid Stenosis, Alzheimer DiseaseArmsApplication of new pulse sequence package SIGNATURES2023 to healthy controls, Application of new pulse sequence package SIGNATURES2023 to 4 groups of patients (pilot)
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Ultrahigh-field MRI: where it really makes a difference.Radiologie (Heidelberg, Germany) · 2024
    Review
  5. Article
  6. Higher striatal glutamate in male youth with internet gaming disorder.European archives of psychiatry and clinical neuroscience · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Guodong WengInstitute for Diagnostic and Interventional Neuroradiology, Support Center for Advanced Neuroimaging (SCAN), University of Bern, Bern, Switzerland.ORCID 0000-0003-3684-5649
Piotr RadojewskiInstitute for Diagnostic and Interventional Neuroradiology, Support Center for Advanced Neuroimaging (SCAN), University of Bern, Bern, Switzerland.
Sulaiman SheriffDepartment of Radiology, University of Miami School of Medicine, Miami, Florida, USA.
Claus KieferInstitute for Diagnostic and Interventional Neuroradiology, Support Center for Advanced Neuroimaging (SCAN), University of Bern, Bern, Switzerland.
Philippe SchuchtDepartment of Neurosurgery, Inselspital Bern and University Hospital, Bern, Switzerland.
Roland WiestInstitute for Diagnostic and Interventional Neuroradiology, Support Center for Advanced Neuroimaging (SCAN), University of Bern, Bern, Switzerland.
Andrew A MaudsleyDepartment of Radiology, University of Miami School of Medicine, Miami, Florida, USA.ORCID 0000-0001-7653-3063
Johannes SlotboomInstitute for Diagnostic and Interventional Neuroradiology, Support Center for Advanced Neuroimaging (SCAN), University of Bern, Bern, Switzerland.ORCID 0000-0001-5121-9852
University of Bern · CHUniversity of Miami · USUniversity Hospital of Bern · CH

Funding

Development and Maintenance of Software for MR Spectroscopic ImagingR01EB016064 · NIBIB · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MAUDSLEY, ANDREW A. · 2013 to 2021
$2.0M
NIBIB NIH HHS R01 EB016064
6 · The paper itself

Abstract

purposeAt ultra-high field (UHF), B

methodsSlice-selective adiabatic refocusing RF-pulses (2π-SSAP) dominate the SAR to the patient in (semi)LASER based MEGA-editing sequences, causing large CSDA and long measurement times to fulfill SAR requirements, even using SAR-minimized GOIA-pulses. Therefore, a novel type of spectral-editing, called SLOW-editing, using two different pairs of phase-compensated chemical-shift selective adiabatic refocusing-pulses (2π-CSAP) with different refocusing bandwidths were investigated to overcome these problems.

resultsCompared to conventional echo-planar spectroscopic imaging (EPSI) and MEGA-editing, SLOW-editing shows robust refocusing and editing performance despite to B

conclusionA new spectral-editing has been developed that is especially suitable for UHF, and was successfully applied for 2HG, GABA+, PE, and Glx-editing within 10 min clinical acceptable measurement time.

Indexed as

BrainMagnetic Fieldsgamma-Aminobutyric AcidHumansLipidsMagnetic Resonance ImagingMagnetic Resonance SpectroscopyPhantoms, ImagingWatergamma-Aminobutyric AcidLipidsWater1H MRSI7Tadiabatic pulsechemical selectiveJ-difference editingwhole-brain

Identifiers

PMID35344608
PMCPMC9212787
OpenAlexW4220652771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.