ReviewCirculation2022
Takotsubo Syndrome: Pathophysiology, Emerging Concepts, and Clinical Implications.
Review in Circulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 226 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
226 citing papers in PubMed, 7 syntheses or guidelines pooled it, 337 citations in OpenAlex.
- Practical guidance for echocardiography for cancer therapy-related cardiac dysfunction: 2026 focused update.Journal of echocardiography · 2026Guideline
- Predictors of high-grade atrioventricular block recovery in Takotsubo cardiomyopathy: a systematic review of case reports.Open heart · 2026Pooled it
- Grief-Related Chest Pain: A Review, Conceptual Analysis, and Integrative Model.Psychophysiology · 2026Pooled it
- MicroRNAs in Takotsubo Syndrome: A Systematic Review of Regulatory Networks in Stress-Induced Cardiomyopathy.International journal of molecular sciences · 2025Pooled it
- Tranexamic acid-induced anaphylaxis: a systematic review.European journal of clinical pharmacology · 2025Pooled it
- The association between integrating echocardiography use in the management of septic shock patients and outcomes in the intensive care unit: a systematic review and meta-analysis.Journal of ultrasound · 2025Pooled it
- Patient with Gender Dysphoria Diagnosed with Multiple Sclerosis Following Takotsubo Cardiomyopathy and Ventricular Arrhythmia: A Case Report and Systematic Literature Review.Internal medicine (Tokyo, Japan) · 2024Pooled it
- Randomized Controlled Trial of Internet-Delivered Cognitive Behavioral Therapy After Myocardial Infarction With Nonobstructive Coronary Arteries or Takotsubo Syndrome.Journal of the American Heart Association · 2026Trial
- Physical Exercise or Cognitive Behavioral Therapy for Takotsubo Cardiomyopathy: A Randomized Controlled Trial.Circulation. Heart failure · 2026Trial
- Redesigning cardiovascular medicine around sex differences.Nature medicine · 2026Review
- Ventricular Arrhythmias: Epidemiology, Diagnosis and Treatment.Journal of cardiovascular development and disease · 2026Article
- Takotsubo cardiomyopathy after aveirJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Transient Midcavity Obstruction from Hyperdynamic Mid-Left Ventricular Segments during Recovery from Classical Takotsubo Syndrome.CASE (Philadelphia, Pa.) · 2026Article
- Neurocardiology: Brain-Heart Interactions in the Heart.MedComm · 2026Review
- The 2 Faces of Takotsubo Syndrome: Why the Initial Presentation Defines the Clinical Trajectory.JACC. Asia · 2026Article
- Non-ACS Presentation in Takotsubo Syndrome: A High-Risk Phenotype with Distinct Treatment Patterns and Worse Outcomes.JACC. Asia · 2026Article
- Bridging Minds and Hearts by Exploring the Comorbidities Between Anxiety, Depression, and Takotsubo Cardiomyopathy: A Scoping Review.Journal of clinical medicine · 2026Review
- Apical ballooning (takotsubo cardiomyopathy) in mid-ventricular obstructive hypertrophic cardiomyopathy.European heart journal. Case reports · 2026Article
- Neurovascular interactions in the ageing heart.Nature reviews. Cardiology · 2026Review
- Hemodynamic characterization of cardiac dysfunction after traumatic brain injury using a controlled cortical impact model in male rats.Physiological reports · 2026Article
166 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Takotsubo syndrome is a condition characterized by acute transient left ventricular systolic dysfunction, which at presentation can be challenging to distinguish from acute myocardial infarction. Although previously thought to be a benign, self-limiting condition, recent studies have confirmed that patients with takotsubo syndrome have persistent subtle ongoing cardiac dysfunction, and many continue to have limiting symptoms despite restoration of left ventricular ejection fraction. Moreover, these patients have a substantial burden of morbidity and mortality, as well, with high rates of subsequent major adverse cardiovascular events that approach those of patients with acute coronary syndrome. The mechanisms behind this condition remain elusive. Despite substantial research, the medical community continues to have an incomplete understanding of its underlying pathogenesis and pathophysiology. Catecholamine-induced myocardial injury is the most established and well-known theory, but this does not explain all the clinical features and presentations of the condition, and numerous other pathways and abnormalities are emerging. Because of the poor understanding of its underlying pathophysiology, there is a lack of evidence-based interventions to treat the acute episode, to avoid recurrences, and to prevent major adverse cardiovascular events. This highlights the need for further research to gain a better understanding of the underlying pathophysiology to inform appropriate randomized controlled trials of interventions targeting the causative pathways. Only then can evidence-based management strategies be established to improve clinical outcomes of this potentially lethal condition.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.