Evidence map›Paper›PMID 35344326›Full record

ArticleACS applied materials & interfaces2022

Controlled and Selective Photo-oxidation of Amyloid-β Fibrils by Oligomeric

Adeline M Fanni, Daniel Okoye, Florencia A Monge, Julia Hammond, Fahimeh Maghsoodi, Tye D Martin, Gabriella Brinkley, M Lisa Phipps, Deborah G Evans, Jennifer S Martinez and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Adeline M FanniCenter for Biomedical Engineering, University of New Mexico, Albuquerque, New Mexico 87131, United States.ORCID https://orcid.org/0000-0002-7240-2792
Daniel OkoyeCenter for Biomedical Engineering, University of New Mexico, Albuquerque, New Mexico 87131, United States.
Florencia A MongeCenter for Biomedical Engineering, University of New Mexico, Albuquerque, New Mexico 87131, United States.
Julia HammondDepartment of Chemical and Biological Engineering, University of New Mexico, Albuquerque, New Mexico 87131, United States.
Fahimeh MaghsoodiNanoscience and Microsystems Engineering Graduate Program, University of New Mexico, Albuquerque, New Mexico 87131, United States.
Tye D MartinCenter for Biomedical Engineering, University of New Mexico, Albuquerque, New Mexico 87131, United States.ORCID https://orcid.org/0000-0002-0987-0606
Gabriella BrinkleyDepartment of Chemical and Biological Engineering, University of New Mexico, Albuquerque, New Mexico 87131, United States.
M Lisa PhippsCenter for Integrated Nanotechnologies, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States.
Deborah G EvansDepartment of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131, United States.ORCID https://orcid.org/0000-0003-2446-6967
Jennifer S MartinezCenter for Materials Interfaces in Research and Applications, Northern Arizona University, Flagstaff, Arizona 86011, United States.ORCID https://orcid.org/0000-0001-6737-2712
David G WhittenCenter for Biomedical Engineering, University of New Mexico, Albuquerque, New Mexico 87131, United States.ORCID https://orcid.org/0000-0002-6305-9494
Eva Y ChiCenter for Biomedical Engineering, University of New Mexico, Albuquerque, New Mexico 87131, United States.ORCID https://orcid.org/0000-0001-7448-9943
University of New Mexico · USLos Alamos National Laboratory · USNorthern Arizona University · US

Funding

FAIR Data Competency and Machine Learning Readiness for Biomedical ScientistsK12GM088021 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI REBECCA S. HARTLEY, Diane Lidke · 2009 to 2026
$16.4M
UNM PREP (Post-baccalaureate Research Education ProgramR25GM075149 · NIGMS · UNIVERSITY OF NEW MEXICO · PI Kelly Miller · 2005 to 2026
$7.3M
Novel Sensors for Detecting Protein Aggregates in Neurodegenerative DiseasesR21NS111267 · NINDS · UNIVERSITY OF NEW MEXICO · PI CHI, EVA YUNGHUA · 2019 to 2019
$402k
NIGMS NIH HHS K12 GM088021NIGMS NIH HHS R25 GM075149NINDS NIH HHS R21 NS111267
6 · The paper itself

Abstract

Photodynamic therapy (PDT) has been explored as a therapeutic strategy to clear toxic amyloid aggregates involved in neurodegenerative disorders such as Alzheimer's disease. A major limitation of PDT is off-target oxidation, which can be lethal for the surrounding cells. We have shown that a novel class of oligo-

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAmyloidAmyloidogenic ProteinsHumansPeptide FragmentsProtein Conformation, beta-StrandAmyloidAmyloid beta-PeptidesAmyloidogenic ProteinsPeptide FragmentsAlzheimer’s diseaseamyloid aggregatesfibril disassemblyoligo-p-phenylene ethylenephoto-oxidation

Identifiers

PMID35344326
PMCPMC10452927
OpenAlexW4220754368

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.