ArticleClinical and translational allergy2022
Allergen immunotherapy in MASK-air users in real-life: Results of a Bayesian mixed-effects model.
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Article in Clinical and translational allergy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 15 citations in OpenAlex.
- ARIA-EAACI 2025: Person-Centred, Digitally Enabled and Artificial Intelligence-Assisted Change Management in Airway Diseases: An OECD Best Practice for Integrated Care for Chronic Diseases.Clinical and translational allergy · 2026Article
- Preparing Allergists to Practice in 2050 Using Artificial Intelligence.The journal of allergy and clinical immunology. In practice · 2025Review
- Concurrent validity, cut-offs and ability to change of patient-reported outcome measures for rhinitis and asthma in MASK-airClinical and translational allergy · 2024Article
- Why the role of mHealth in allergy diagnosis and treatment adherence cannot be overlooked.Clinical and translational allergy · 2023Review
- Molecular sensitization pattern to house dust mites is formed from the first years of life and includes group 1, 2, Der p 23, Der p 5, Der p 7 and Der p 21 allergens.Clinical and molecular allergy : CMA · 2023Article
- Real-life evidence in allergen immunotherapy: Moving forward with mHealth apps.Allergologie select · 2023Review
- Digitally-enabled, patient-centred care in rhinitis and asthma multimorbidity: The ARIA-MASK-airClinical and translational allergy · 2023Article
- Real-world data using mHealth apps in rhinitis, rhinosinusitis and their multimorbidities.Clinical and translational allergy · 2022Article
- Allergen immunotherapy in MASK-air users in real-life: Results of a Bayesian mixed-effects model.Clinical and translational allergy · 2022Article
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Authors and funding
70 authors at 20 institutions in 29 countries.
Bernardo Sousa-PintoMEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.ORCID https://orcid.org/0000-0002-1277-3401
Luís Filipe AzevedoMEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Ana Sá-SousaMEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Rafael José VieiraMEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Rita AmaralMEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Ludger KlimekDepartment of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany.
Wienczyslawa CzarlewskiMedical Consulting Czarlewski, Levallois, France.
Josep M AntoISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.
Anna BedbrookMASK-air, Montpellier, France.
Violeta KvedarieneInstitute of Biomedical Sciences, Department of Pathology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Maria Teresa VenturaUniversity of Bari Medical School, Unit of Geriatric Immunoallergology, Bari, Italy.
Ignacio J AnsoteguiDepartment of Allergy and Immunology, Hospital Quirónsalud Bizkaia, Bilbao, Spain.
Karl-Christian BergmannInstitute of Allergology, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-0306-9922
Luisa BrussinoDepartment of Medical Sciences, Allergy and Clinical Immunology Unit, University of Torino & Mauriziano Hospital, Torino, Italy.
G Walter CanonicaDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Victoria CardonaAllergy Section, Department of Internal Medicine, Hospital Vall d'Hebron & ARADyAL Research Network, Barcelona, Spain.ORCID https://orcid.org/0000-0003-2197-9767
Pedro Carreiro-MartinsServiço de Imunoalergologia, Hospital de Dona Estefânia, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal.
Thomas CasaleDivision of Allergy/immunology, University of South Florida, Tampa, Florida, USA.
Lorenzo CecchiSOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy.
Tomás ChivatoSchool of Medicine, University CEU San Pablo, Madrid, Spain.
Derek K ChuDepartment of Medicine and Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada.
Cemal CingiEskisehir Osmangazi University, Medical Faculty, ENT Department, Eskisehir, Turkey.
Elisio M CostaUCIBIO, REQUINTE, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing of University of Porto (Porto4Ageing), Porto, Portugal.
Alvaro A CruzFundaçao ProAR, Federal University of Bahia, Salvador, Bahia, Brazil.
Giulia De FeoDepartment of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, Salerno, Italy.
Philippe DevillierVIM Suresnes, UMR_0892, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris-Saclay, Suresnes, France.
Wytske J FokkensDepartment of Otorhinolaryngology, Amsterdam University Medical Centres, location AMC, Amsterdam, The Netherlands.
Mina GagaERS President 2017-2018, Athens Chest Hospital, 7th Respiratory Medicine Department and Asthma Center, Athens, Greece.
Bilun GemicioğluDepartment of Pulmonary Diseases, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
Tari HaahtelaSkin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Juan Carlos IvancevichServicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina.
Zhanat IspayevaDepartment of Allergology and Clinical Immunology of the Kazakh National Medical University, Almaty, Kazakhstan.
Marek JutelDepartment of Clinical Immunology, Wrocław Medical University, Wroclaw, Poland.
Piotr KunaDivision of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland.
Igor KaidashevPoltava State Medical University, Poltava, Ukraine.
Helga KraxnerDepartment of Otorhinolaryngology, Head and Neck Surgery, Semmelweis University, Budapest, Hungary.
Désirée E Larenas-LinnemannCenter of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico.
Daniel LauneKYomed INNOV, Montpellier, France.
Brian LipworthScottish Centre for Respiratory Research, Cardiovascular & Diabetes Medicine, Medical Research Institute, Ninewells Hospital, University of Dundee, Dundee, UK.
Renaud LouisDepartment of Pulmonary Medicine, CHU Sart-Tilman, Liege, Belgium.
Michaël MakrisAllergy Unit 'D Kalogeromitros', 2nd Department of Dermatology and Venereology, National & Kapodistrian University of Athens, 'Attikon' University Hospital, Chaidari, Greece.
Riccardo MontiDepartment of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario A Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Mario Morais-AlmeidaAllergy Center, CUF Descobertas Hospital, Lisbon, Portugal.
Ralph MösgesClinCompetence Cologne GmbH, Cologne, Germany.ORCID https://orcid.org/0000-0002-1928-810X
Joaquim MullolRhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, Barcelona, Spain.
Mikaëla OdemyrEFA European Federation of Allergy and Airways Diseases Patients' Associations, Brussels, Belgium.
Yoshitaka OkamotoDepartment of Otorhinolaryngology, Chiba University Hospital, Chiba, Japan.
Nikolaos G PapadopoulosAllergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.
Vincenzo PatellaDivision of Allergy and Clinical Immunology, Department of Medicine, Agency of Health ASL Salerno, 'Santa Maria della Speranza' Hospital, Salerno, Italy.
Nhân Pham-ThiEcole Polytechnique Palaiseau, IRBA (Institut de Recherche bio-Médicale des Armées), Bretigny, France.
Frederico S RegateiroMEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Sietze ReitsmaDepartment of Otorhinolaryngology, Amsterdam University Medical Centres, location AMC, Amsterdam, The Netherlands.
Philip W RouadiDepartment of Otolaryngology-Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon.
Boleslaw SamolinskiDepartment of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland.
Milan SovaDepartment of Pulmonary Medicine and Tuberculosis, University Hospital Brno, Liskovec, Czech Republic.
Ana Todo-BomMEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Luis Taborda-BarataFaculty of Health Sciences, University of Beira Interior, Covilhã, Portugal.
Peter Valentin TomazicDepartment of General ORL, H&NS, Medical University of Graz, ENT-University Hospital Graz, Graz, Austria.
Sanna Toppila-SalmiSkin and Allergy Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Joaquin SastreFundacion Jimenez Diaz, CIBERES, Faculty of Medicine, Autonoma University of Madrid, Madrid, Spain.
Ioanna TsiligianniHealth Planning Unit, Department of Social Medicine, Faculty of Medicine, University of Crete, Rethymno, Greece.
Arunas ValiulisInstitute of Clinical Medicine and Institute of Health Sciences, Medical Faculty of Vilnius University, Vilnius, Lithuania.
Dana WallaceNova Southeastern University, Fort Lauderdale, Florida, USA.
Susan WasermanDepartment of Medicine, Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada.
Arzu YorganciogluDepartment of Pulmonology, Celal Bayar University, Manisa, Turkey.
Mihaela ZidarnUniversity Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia.ORCID https://orcid.org/0000-0003-0515-5207
Torsten ZuberbierInstitute of Allergology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
João Almeida FonsecaMEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Jean BousquetInstitute of Allergology, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-4061-4766
Oliver PfaarDepartment of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.ORCID https://orcid.org/0000-0003-4374-9639
Universidade do Porto · PTAmsterdam University Medical Centers · NLHumboldt-Universität zu Berlin · DENational and Kapodistrian University of Athens · GRUniversity of Helsinki · FIUniversity of Ljubljana · SIVilnius University · LTAzienda Usl Toscana Centro · ITChiba University Hospital · JPCUF Porto Hospital · PTÉcole Polytechnique · FREskişehir Osmangazi University · TREuropean Federation of Allergy and Airways Diseases Patients Associations · BEHospital Alemán · ARHospital Clínic de Barcelona · ESHospital de Dona Estefânia · PTHospital Médica Sur · MXHospital Quirónsalud Barcelona · ESHospital Universitario Fundación Jiménez Díaz · ESHumanitas University · IT
Funding
ALKCharité Universitätsmedizin BerlinEIT Health POLLAREIT Health TwinningGSKMylan-ViatrisNovartisUriach
Abstract
backgroundEvidence regarding the effectiveness of allergen immunotherapy (AIT) on allergic rhinitis has been provided mostly by randomised controlled trials, with little data from real-life studies.
objectiveTo compare the reported control of allergic rhinitis symptoms in three groups of users of the MASK-air
methodsWe assessed the MASK-air
resultsWe analysed a total of 42,756 days from 1,093 grass allergy patients, including 18,479 days of users under AIT. Compared to no AIT, SCIT was associated with similar VAS levels and CSMS. Compared to no AIT, SLIT-tablet was associated with lower values of VAS global allergy symptoms (average difference = 7.5 units out of 100; 95% credible interval [95%CrI] = -12.1;-2.8), lower VAS Work (average difference = 5.0; 95%CrI = -8.5;-1.5), and a lower CSMS (average difference = 3.7; 95%CrI = -9.3;2.2). When compared to SCIT, SLIT-tablet was associated with lower VAS global allergy symptoms (average difference = 10.2; 95%CrI = -17.2;-2.8), lower VAS Work (average difference = 7.8; 95%CrI = -15.1;0.2), and a lower CSMS (average difference = 9.3; 95%CrI = -18.5;0.2).
conclusionIn patients with grass pollen allergy, SLIT-tablet, when compared to no AIT and to SCIT, is associated with lower reported symptom severity. Future longitudinal studies following internationally-harmonised standards for performing and reporting real-world data in AIT are needed to better understand its 'real-world' effectiveness.
Indexed as
allergic rhinitisimmunotherapymobile healthpatient-reported outcomesreal-life data analysis
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