Evidence map›Paper›PMID 35344187›Full record

ReviewCardiology and therapy2022

Coronary Artery Disease and Aspirin Intolerance: Background and Insights on Current Management.

Ravi A Thakker, Leonardo Salazar, Deaa Abu Jazar, Pooja Bhakta, Bryan Baker, Chandani Patel, Ayman Elbadawi, Mayank Agarwal, Aiham Albaeni, Mohammed Saleh and 12 more

Open access · goldAbstract readReview
In one paragraph

Review in Cardiology and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Indobufen Dual Antiplatelet Therapy (DAPT) Versus Aspirin Dual Antiplatelet Therapy (DAPT) After Percutaneous Coronary Intervention (PCI): A Systematic Review and Meta-Analysis.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
    Pooled it
  2. Comparison of the Effects of Indobufen and Aspirin in Older Patients with Coronary Artery Disease After Coronary Drug-Eluting Stent Implantation: A Prospective Randomized Single-Center Study.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Trial
  3. Article
  4. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
    Article
  5. Allergy to acetylsalicylic acid among patients with acute coronary syndrome.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 5 institutions in 1 country.

Ravi A ThakkerDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, 77555, USA. ravi.a.thakker@gmail.com.ORCID http://orcid.org/0000-0001-7214-3439
Leonardo SalazarDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Deaa Abu JazarDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Pooja BhaktaDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Bryan BakerDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Chandani PatelDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Ayman ElbadawiDivision of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Mayank AgarwalDivision of Cardiology, University of Texas Medical Branch, Galveston, TX, USA.
Aiham AlbaeniDivision of Cardiology, University of Texas Medical Branch, Galveston, TX, USA.
Mohammed SalehDivision of Cardiology, University of Texas Medical Branch, Galveston, TX, USA.
Jonathan EsclovanDivision of Cardiology, University of Texas Medical Branch, Galveston, TX, USA.
Danielle El HaddadDivision of Cardiology, University of Texas Medical Branch, Galveston, TX, USA.
Hashim AlwashDivision of Cardiology, University of Texas Medical Branch, Galveston, TX, USA.
Ankur KalraDivision of Cardiovascular Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Sachin S GoelDepartment of Cardiology, Houston Methodist DeBakey Heart and Vascular Center, Houston, TX, USA.
Robert Jay WidmerDivision of Cardiology, Scott and White Heart Memorial Hospital, Baylor Scott and White Health, Temple, TX, USA.
Khaled ChatilaDivision of Cardiology, University of Texas Medical Branch, Galveston, TX, USA.
Wissam KhalifeDivision of Cardiology, University of Texas Medical Branch, Galveston, TX, USA.
Afaq MotiwalaDivision of Cardiology, University of Texas Medical Branch, Galveston, TX, USA.
Jennifer McCrackenDivision of Allergy and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Hani JneidDivision of Cardiology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Syed GilaniDivision of Cardiology, University of Texas Medical Branch, Galveston, TX, USA.
The University of Texas Medical Branch at Galveston · USBaylor College of Medicine · USHouston Methodist · USIndiana University School of MedicineScott & White Memorial Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aspirin is one of the most widely used medications across the global healthcare system and is the foundation in treating ischemic heart disease, as well as secondary prevention for ischemic and valvular heart disease. Challenges arise in treating patients with cardiovascular disease who have concomitant aspirin intolerance. Through an extensive review of the literature, we provide a comprehensive background on the pharmacology of aspirin, the mechanisms behind aspirin intolerance, the importance of aspirin in cardiovascular disease, and the management of aspirin intolerance in both acute coronary syndrome and stable coronary artery disease. Our review includes a multidisciplinary approach from the internist, allergist/immunologist, and cardiologist when evaluating this important patient population.

Indexed as

Acute coronary syndromeAspirin intoleranceCoronary artery disease

Identifiers

PMID35344187
PMCPMC9135937
OpenAlexW4221123104

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.