Evidence map›Paper›PMID 35344150›Full record

SynthesisTechniques in coloproctology2022

Surgical outcomes of Turnbull-Cutait delayed coloanal anastomosis with pull-through versus immediate coloanal anastomosis with diverting stoma after total mesorectal excision for low rectal cancer: a systematic review and meta-analysis.

C La Raja, C Foppa, A Maroli, C Kontovounisios, N Ben David, M Carvello, A Spinelli

2 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Techniques in coloproctology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06662643 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

A Prospective, Multicenter, Randomized Controlled Clinical Trial Comparing Staged Turnbull-Cutait Pull-through Anastomosis With Direct Anastomosis Plus Prophylactic Ileostomy in the Treatment of Low Rectal Cancer After Internal Sphincter Resection

TypeinterventionalSponsorZhongnan HospitalRan2024 to 2029Enrolled110ConditionsRectal Cancer, Rectal CarcinomaArmsDelayed transanal pull-through anastomosis, Direct Anastomosis Plus Prophylactic Ileostomy
NCT07369531 narecruitingnot on this mapstarted 2026, after this paper: background citation

The Impact of Two-Stage Turnbull-Cutait Pull-Through Coloanal Anastomosis on Stoma-free Survival in Low Rectal Anal-preserving Surgery: A Multicenter Randomized Controlled Trial (FIAS)

TypeinterventionalSponsorThe First Hospital of Jilin UniversityRan2026 to 2031Enrolled520ConditionsRectal Cancer, Surgical Anastomosis, Survival , Tumor, Anal FunctionArmsTurnbull-Cutait anastomosis, LAR
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

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  5. Turnbull procedure-analysis of a cohort in the salvage setting.International journal of colorectal disease · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

C La RajaDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
C FoppaDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
A MaroliDivision of Colon and Rectal Surgery, IRCCS Humanitas Research Hospital, via Manzoni 56, 20089, Rozzano, Milan, Italy.
C KontovounisiosDepartment of Surgery and Cancer, Imperial College London, London, UK.
N Ben DavidDivision of Colon and Rectal Surgery, IRCCS Humanitas Research Hospital, via Manzoni 56, 20089, Rozzano, Milan, Italy.
M CarvelloDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
A SpinelliDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy. antonino.spinelli@hunimed.eu.ORCID 0000-0002-1493-1768
Humanitas University · ITIRCCS Humanitas Research Hospital · ITRoyal Marsden Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTheoretical advantages of Turnbull-Cutait pull-through delayed coloanal anastomosis (DCAA) are a reduced risk of anastomotic leak and therefore avoidance of stoma. Gradually abandoned in favor of immediate coloanal anastomosis (ICAA) with diverting stoma, DCAA has regained popularity in recent years in reconstructive surgery for low RC, especially when combined with minimally invasive surgery (MIS). The aim of this study was to perform the first meta-analysis, exploring the safety and outcomes of DCAA compared to ICAA with protective stoma.

methodsA systematic search of MEDLINE, EMBASE, and CENTRAL and Google Scholar databases was performed for studies published from January 2000 until December 2020. The systematic review and meta-analysis were performed according to the Cochrane Handbook for Systematic Review on Interventions recommendations and Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines.

resultsOut of 2626 studies screened, 9 were included in the systematic review and 4 studies in the meta-analysis. Outcomes included were postoperative complications, pelvic sepsis and risk of definitive stoma. Considering postoperative complications classified as Clavien-Dindo III, no significant difference existed in the rate of postoperative morbidity between DCAA and ICAA (13% versus 21%; OR 1.17; 95% CI 0.38-3.62; p = 0.78; I

conclusionsAccording to the limited current evidence, DCAA is associated with a significant decrease in pelvic sepsis. Further prospective trials focusing on oncologic and functional outcomes are needed.

Indexed as

Rectal NeoplasmsSepsisAnal CanalAnastomosis, SurgicalAnastomotic LeakColonHumansPostoperative ComplicationsRetrospective StudiesTreatment OutcomeAnastomotic leakDelayed coloanal anastomosisDiverting stomaPull-throughRectal cancer

Identifiers

PMID35344150
OpenAlexW4220654674

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.