Evidence map›Paper›PMID 35344119›Full record

ArticleAnnals of biomedical engineering2022

Effect of Assistance Using a Bilateral Robotic Knee Exoskeleton on Tibiofemoral Force Using a Neuromuscular Model.

Bailey J McLain, Dawit Lee, Sierra C Mulrine, Aaron J Young

Abstract read
PubMed Publisher
In one paragraph

Article in Annals of biomedical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Optimal Energy Shaping and Force Amplification Framework for Task-Agnostic, Biomimetic Ankle Exoskeletons.IEEE transactions on robotics : a publication of the IEEE Robotics and Automation Society · 2026
    Article
  3. Article
  4. Task-Agnostic Exoskeleton Torque Assistance Reduces Ankle Osteoarthritis Pain: A Pilot Study.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025
    Article
  5. Human-Interface Dynamics of Knee Exoskeletons with Lateral and Anteroposterior Attachment.IEEE ... International Conference on Rehabilitation Robotics : [proceedings] · 2025
    Article
  6. Biomechanical models in the lower-limb exoskeletons development: a review.Journal of neuroengineering and rehabilitation · 2025
    Review
  7. Article
  8. A Data-Driven Approach to Estimate Changes in Peak Knee Contact Force With Exoskeleton Assistance.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Bailey J McLainWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 813 Ferst Dr. NW, Atlanta, GA, 30332, USA. bmclain3@gatech.edu.ORCID http://orcid.org/0000-0002-3033-4621
Dawit LeeWoodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-2972-0082
Sierra C MulrineWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, 813 Ferst Dr. NW, Atlanta, GA, 30332, USA.ORCID http://orcid.org/0000-0002-8058-4688
Aaron J YoungWoodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-5376-2258
Georgia Institute of Technology · US

Funding

NSF NRI Award 1830498
6 · The paper itself

Abstract

Tibiofemoral compression forces present during locomotion can result in high stress and risk damage to the knee. Powered assistance using a knee exoskeleton may reduce the knee load by reducing the work required by the muscles. However, the exact effect of assistance on the tibiofemoral force is unknown. The goal of this study was to investigate the effect of knee extension assistance during the early stance phase on the tibiofemoral force. Nine able-bodied adults walked on an inclined treadmill with a bilateral knee exoskeleton with assistance and with no assistance. Using an EMG-informed neuromusculoskeletal model, muscle forces were estimated, then utilized to estimate the tibiofemoral contact force. Results showed a 28% reduction in the knee moment, which resulted in approximately a 15% decrease in knee extensor muscle activation and a 20% reduction in subsequent muscle force, leading to a significant 10% reduction in peak and 9% reduction in average tibiofemoral contact force during the early stance phase (p < 0.05). The results indicate the tibiofemoral force is highly dependent on the knee kinetics and quadricep muscle activation due to their influence on knee extensor muscle forces, the primary contributor to the knee load.

Indexed as

Exoskeleton DeviceRobotic Surgical ProceduresAdultBiomechanical PhenomenaGaitHumansKneeKnee JointBiomechanicsJoint loadMusculoskeletal modeling

Identifiers

PMID35344119
OpenAlexW4220975213

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.